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Insulinoma is the most common functional neuroendocrine tumor that originates from the islet of beta cells [1]. Advances of various diagnostic imaging methods have dramatically increased our ability to detect pancreatic diseases [2]. In particular, the ultrasonography plays an important role in the screening of pancreatic ailments [3]. Due to the small dimension of the mass, the clinicians face difficulties in diagnosing it. We present the case of a 69 years old patient diagnosed with pancreatic insulinoma which underwent imagistic examination. The patient known with hypertension and non-alcoholic steatohepatitis presented in the clinic for syncopes, sweating, anxiety and severe wight-loss. In the patient medical history, we found an emergency admission one month earlier for episodes of loss of consciousness, tremor of the upper limbs, sweating and disorientation in time and space. Abdominal ultrasonography and computed tomography showed a heterogenous 1,4 cm tumour localized in the pancreatic body with features of insulinoma. The prolonged supervised fast test that was applied induced hypoglycaemic symptoms. The level of glucose and insulin was at the lower range of the fast test. The presence of tumor was confirmed by endoscopic ultrasound, but the cytopathologic examination suggested an aspect of chronic pancreatitis. Through imaging methods and with an evocative clinical portrayal, we identified the pancreatic tumor as being an insulinoma. Even though cytology didn't support the diagnosis, we tend to believe that a false negative result cannot be ruled out. We underline the need of other specific tests in this situation. [ABSTRACT FROM AUTHOR]

Colorectal cancer is the third most common malignancy worldwide. We report the case of a 66-yearold man diagnosed with stage III B colorectal cancer who underwent radical surgery, adjuvant chemotherapy and subsequently developed hepatic metastases. Two months following metastasectomy, PET-CT scan revealed liver metastases with metabolic activity. The patient was started on FOLFIRI chemotherapy regimen in combination with cetuximab, and achieved stable partial remission 7 weeks after starting the treatment. NGS and IHC testing of the surgically removed tumor revealed MSI-H/dMMR, and NRAS/KRAS wild type status, moderate positive (30%) expression of PD-L1 protein, along with BRCA2 mutation [ABSTRACT FROM AUTHOR]

Optical coherence tomography (OCT) is a noninvasive, high-resolution, high-potential imaging method that has recently been introduced into medical investigations. A growing number of studies have used this technique in the field of gastroenterology in order to assist classical analyses. Lately, 3D-imaging and Doppler capabilities have been developed in different configurations, which make this type of investigation more attractive. This paper reviews the principles and characteristics of OCT and Doppler-OCT in connection with analyses of the detection of normal and pathological structures, and with the possibility to investigate angiogenesis in the gastrointestinal tract. [ABSTRACT FROM AUTHOR]