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Objective: Myelodysplastic syndrome (MDS) represents one of the most frequent and serious hematologic diseases among the elderly. Chromosomal abnormalities have been detected in 23%-78% patients with MDS. We analyzed the cytogenetics of elderly MDS patients in Turkey. Materials and Methods: Data on patients (>65 years old) diagnosed with primary MDS from 2011 to 2013 were retrospectively collected from Erciyes University. Chromosome analysis was performed in 54 patients using conventional karyotyping and fluorescence in situ hybridization (FISH). Results: Of the 54 patients recruited, karyotype abnormalities were found in 8 (15%) of 54 cases, among which, 5 (9%) were Trisomy 8 and 3 (6%) were del 5q. Conclusion: The incidence of chromosomal abnormalities in elderly Turkish MDS patients was lower than that reported in the literature. Although the pathogenesis of MDS is still poorly understood, environmental and biological factors could induce mechanisms that are associated with diverse karyotypes and variable frequencies of chromosomal abnormalities. [ABSTRACT FROM AUTHOR]

Objective: Our aim was to evaluate the contribution of flow cytometry (FC) analysis in patients with a histopathological diagnosis of mantle cell lymphoma (MCL) and to develop a reliable scoring system. Materials and Methods: We assessed the results of FC analysis in peripheral blood or bone marrow samples of 36 patients diagnosed with MCL by histopathological evaluation. Multivariate analysis identified 5 variables associated with MCL: CD23 negativity, CD5/19 common positivity, CD20/22 common bright positivity, FMC7 positivity, and clonal sIg bright positivity. A 5-point scoring system was devised using these parameters. Results: Twenty-five patients (69.4%) scored 5 points, 8 (22.2%) scored 4 points, and 3 (8.4%) scored 3 points. The diagnosis of MCL was confirmed by FC immunophenotyping in 91.6% of the patients. Conclusion: Our results suggest that a quintet diagnostic scoring system, which is considered to be reliable in the diagnosis of MCL, could make a substantial contribution to diagnosis and should be more widely introduced in practice. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 63-year-old male who was diagnosed with acute promyelocytic leukemia after evaluation of peripheral blood smear and bone marrow. The patient developed fever, infraorbital edema, and yellow-black discoloration of the upper palate after undergoing chemotherapy which included cytarabine and idarubicin. The patient died on 30th day of hospitalization after surgical debridement. It also discusses mucormycosis.

Objectives and Aim In this study, we aimed to compare the potency of different G-CSF agents including original filgrastim (Neupogen®), biosimilar filgrastim (Leucostim®) and Lenograstim (Granocyte®) on CD34 + cell mobilization in patients that underwent allogeneic hematopoietic stem cell transplantation (alloHSCT). Patients and Methods The data of 243 donors for alloHSCT recipients diagnosed with mostly acute leukemia and myelodsyplastic syndromes (MDS) were analyzed, retrospectively. Data for stem cell mobilization have been recorded from patients' files. Donors who received Filgrastim (Neupogen®, Group I), biosimilar Filgrastim (Leucostim®, Group II) and Lenograstim (Granocyte®, Group III) were analyzed for total CD34 + cell count at the end of mobilization procedures. Results A total of 243 donors and patients for alloHSCT were analyzed retrospectively. The diagnosis of the patients were; acute myeloid leukemia (AML) (110 patients, 45.2%), acute lymphoid leukemia (ALL) (61 patients, 25.1%), aplastic anemia (AA) (38 patients, 15.6%), lymphomas (14 patients, 5.7%) and others (20 patients, 8.4%). The median number of total collected PB CD34 + cells (×10 6 /kg) was 7.12 (min–max: 5.38–7.90) in the Neupogen® group, 7.27 (min–max: 6.79–7.55) in the Leucostim® group and 7.15 (min–max: 5.34–7.58) in the Granocyte® group. There was no statistically significant difference among groups in terms of total collected PB CD34 + cells (p = 0.919). The median doses of G-CSF agents (µg/kg/day) in PBSC collection in Neupogen® group was; 11.00 (10.00–12.00) in Leucostim® group10.35 (min–max: 10.00–11.10) and in Granocyte® group11.00 (min–max: 10.00–11.00). There was no statistical significance among groups (p = 0.215). Conclusion Biosimilar filgrastim (Leucostim®) was found comparable to original Filgrastim (Neupogen®) and Lenograstim (Granocyte®) for PBSC mobilization in donors of the patients that underwent alloHSCT. [ABSTRACT FROM AUTHOR]