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Objectives: To determine the accuracy of ultrasound in diagnosing biliary atresia taking histopathology as gold standard. Design: Cross Sectional Study. Settings: Department of Diagnostic Radiology and Gastroenterology at Children's Hospital and Institute of Child Health, Lahore. Period: Over 1 year from 13-01-2015 to 12-02-2016. Material and Methods: This study involved 210 infants aged between 2-6 weeks referred from outpatient department and emergency of gastroenterology department with suspicion of biliary atresia. Ultrasound of all these cases was carried out and biliary atresia was labeled on a positive triangular cord sign. Core needle biopsy sample was taken from the liver adjacent to the porta hepatis and histopathological examination was done. Results of histopathology were taken as gold standard and results of ultrasonography were judged accordingly as true positive or false positive. A written informed consent was taken from each patient. A predesigned proforma was used to record patient's demographic details along with ultrasound and histopathological diagnosis. Results: The mean age of the patients was 4.31±1.22 weeks. There were 109 (51.9%) male and 101 (48.1%) female patients with a male to female ratio of 1.1:1. Ultrasound was found 97.5% sensitive, 87.7% specific and 95.2% accurate with positive and negative predictive value of 96.31% and 91.5%, respectively. Conclusion: Ultrasound was found extremely sensitive tool for the diagnosis of biliary atresia. Its non-invasive nature and lack of radiation exposure further make it ideal for pre-operative diagnosis in suspected cases in future practice. [ABSTRACT FROM AUTHOR]