1. Dietary Micronutrient Management to Treat Mitochondrial Dysfunction in Diet-Induced Obese Mice.
- Author
-
Cimmino F, Catapano A, Trinchese G, Cavaliere G, Culurciello R, Fogliano C, Penna E, Lucci V, Crispino M, Avallone B, Pizzo E, and Mollica MP
- Subjects
- Animals, Antioxidants administration & dosage, Diet, High-Fat adverse effects, Disease Models, Animal, Humans, Inflammation etiology, Inflammation metabolism, Inflammation prevention & control, Male, Mice, Inbred C57BL, Mitochondria metabolism, Mitochondria physiology, Obesity etiology, Obesity metabolism, Oxidation-Reduction drug effects, Oxidative Stress drug effects, Mice, Diet, Dietary Supplements, Micronutrients analysis, Mitochondria drug effects, Obesity prevention & control
- Abstract
Obesity and associated metabolic disturbances, which have been increasing worldwide in recent years, are the consequences of unhealthy diets and physical inactivity and are the main factors underlying non-communicable diseases (NCD). These diseases are now responsible for about three out of five deaths worldwide, and it has been shown that they depend on mitochondrial dysfunction, systemic inflammation and oxidative stress. It was also demonstrated that several nutritional components modulating these processes are able to influence metabolic homeostasis and, consequently, to prevent or delay the onset of NCD. An interesting combination of nutraceutical substances, named DMG-gold, has been shown to promote metabolic and physical wellness. The aim of this research was to investigate the metabolic, inflammatory and oxidative pathways modulated by DMG-gold in an animal model with diet-induced obesity. Our data indicate that DMG-gold decreases the metabolic efficiency and inflammatory state and acts as an antioxidant and detoxifying agent, modulating mitochondrial functions. Therefore, DMG-gold is a promising candidate in the prevention/treatment of NCD.
- Published
- 2021
- Full Text
- View/download PDF