1. Novel water-soluble 99mTc(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging
- Author
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Spagnul, Cinzia, Alberto, Roger, Gasser, Gilles, Ferrari, Stefano, Pierroz, Vanessa, Bergamo, Alberta, Gianferrara, Teresa, and Alessio, Enzo
- Subjects
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WATER , *PORPHYRINS , *TECHNETIUM compounds , *BIOCONJUGATES , *DIETHYLENETRIAMINE , *BINDING sites , *SOLUBILITY - Abstract
Abstract: The synthesis and characterization of two novel water soluble porphyrins with three meso pyridyl rings and one peripheral chelator — either a diethylenetriamine unit (4) or a bipyridyl fragment (8) — for binding to the {99mTc(CO)3}+ moiety is reported. In 8, despite the presence of a flexible and hydrophilic PEG-like linker that connects the bpy unit to the macrocycle, good water solubility was only obtained by methylation of the pyridyl N atoms that provided three extra positive charges. Furthermore, the water-soluble conjugates of 4 and 8 with either one fac-{Re(CO)3}+ (9 and 10, respectively) or one fac-{99mTc(CO)3}+ fragment (9a and 10a, respectively) are described. [Copyright &y& Elsevier]
- Published
- 2013
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