Wei Liu, Hao Li, Qing-Bin Lu, Ning Cui, Zhen-Dong Yang, Jian-Gong Hu, Ya-Di Fan, Chen-Tao Guo, Xiao-Kun Li, Ya-Wei Wang, Kun Liu, Xiao-Ai Zhang, Lan Yuan, Pu-Yu Zhao, Shu-Li Qin, Wu-Chun Cao, Liu, Wei, Li, Hao, Lu, Qing-Bin, and Cui, Ning
Background: Human infection with Candidatus Rickettsia tarasevichiae (CRT) was first reported in northeastern China in 2012.Objective: To describe the clinical spectrum and laboratory findings of patients infected with CRT in eastern central China.Design: Case series.Setting: A sentinel hospital for severe fever with thrombocytopenia syndrome (SFTS) in eastern central China in 2014.Participants: Hospitalized patients with SFTS-like illness.Measurements: Molecular and serologic tests were performed to diagnose CRT infection. Data about clinical manifestations and laboratory findings were retrieved from medical records.Results: 56 of 733 assessed patients had CRT based on polymerase chain reaction and sequencing. All patients presented with nonspecific manifestations, including fever (96%), malaise (88%), myalgia (57%), cough (25%), and dizziness (14%). Only 2 patients had rash. Further, 16% had eschar, 29% had lymphadenopathy, 100% had gastrointestinal symptoms, 34% had neurologic symptoms, 43% had hemorrhagic manifestations, and 23% had signs of plasma leakage. Thrombocytopenia was observed in 70%, leukopenia in 59%; lymphopenia in 45%; and elevated levels of lactate dehydrogenase in 82%, aspartate aminotransferase in 70%, alanine aminotransferase in 54%, and creatinine kinase in 46%. Co-infection with SFTS virus was documented in 66% patients, and 8 of the 56 patients died.Limitations: Patients with CRT were not treated for infection because they were retrospectively identified. This was not a population-based study, and the results cannot be generalized to all patients with CRT.Conclusion: Candidatus R tarasevichiae infection should be considered in the differential diagnosis of febrile patients with SFTS-like illness in endemic areas.Primary Funding Source: National Natural Science Foundation of China. [ABSTRACT FROM AUTHOR]