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Your search keyword '"de Medeiros Rimkus, Carolina"' showing total 3 results
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3 results on '"de Medeiros Rimkus, Carolina"'

1. Clinical and MRI measures to identify non-acute MOG-antibody disease in adults

Author

Cortese, Rosa, Battaglini, Marco, Ferran, Prados, Alessia, Bianchi, Lukas, Haider, Anu, Jacob, Jacqueline, Palace, Silvia, Messina, Friedemann, Paul, Jens, Wuerfel, Romain, Marignier, Françoise, Durand-Dubief, Carolina de Medeiros Rimkus, Dagoberto, Callegaro, Douglas Kazutoshi Sato, Massimo, Filippi, Maria Assunta Rocca, Laura, Cacciaguerra, Alex, Rovira, Jaume, Sastre-Garriga, Georgina, Arrambide, Yaou, Liu, Yunyun, Duan, Claudio, Gasperini, Carla, Tortorella, Serena, Ruggieri, Maria Pia Amato, Ulivelli, Monica, Sergiu, Groppa, Matthias, Grothe, Sara, Llufriu, Maria, Sepulveda, Carsten, Lukas, Barbara, Bellenberg, Ruth, Schneider, Piotr, Sowa, Elisabeth, G Celius, Anne-Katrin, Proebstel, Özgür, Yaldizli, Jannis, Müller, Bruno, Stankoff, Benedetta, Bodini, Luca, Carmisciano, Maria Pia Sormani, Frederik, Barkhof, DE STEFANO, Nicola, Olga, Ciccarelli, Cortese, Rosa, Battaglini, Marco, Prados, Ferran, Bianchi, Alessia, Haider, Luka, Jacob, Anu, Palace, Jacqueline, Messina, Silvia, Paul, Friedemann, Wuerfel, Jen, Marignier, Romain, Durand-Dubief, Françoise, de Medeiros Rimkus, Carolina, Callegaro, Dagoberto, Sato, Douglas Kazutoshi, Filippi, Massimo, Rocca, Maria Assunta, Cacciaguerra, Laura, Rovira, Alex, Sastre-Garriga, Jaume, Arrambide, Georgina, Liu, Yaou, Duan, Yunyun, Gasperini, Claudio, Tortorella, Carla, Ruggieri, Serena, Amato, Maria Pia, Ulivelli, Monica, Groppa, Sergiu, Grothe, Matthia, Llufriu, Sara, Sepulveda, Maria, Lukas, Carsten, Bellenberg, Barbara, Schneider, Ruth, Sowa, Piotr, Celius, Elisabeth G, Proebstel, Anne-Katrin, Yaldizli, Özgür, Müller, Janni, Stankoff, Bruno, Bodini, Benedetta, Carmisciano, Luca, Sormani, Maria Pia, Barkhof, Frederik, De Stefano, Nicola, and Ciccarelli, Olga

Subjects
aquaporin 4-antibody positive neuromyelitis optica spectrum disorder, differential diagnosis, imaging, multiple sclerosis, myelin oligodendrocyte glycoprotein antibody-associated disease, Neurology (clinical)
Abstract

MRI and clinical features of myelin oligodendrocyte glycoprotein (MOG)-antibody disease may overlap with those of other inflammatory demyelinating conditions posing diagnostic challenges, especially in non-acute phases and when serologic testing for MOG antibodies is unavailable or shows uncertain results. We aimed to identify MRI and clinical markers that differentiate non-acute MOG-antibody disease from aquaporin 4 (AQP4)-antibody neuromyelitis optica spectrum disorder and relapsing remitting multiple sclerosis, guiding in the identification of patients with MOG-antibody disease in clinical practice. In this cross-sectional retrospective study, data from 16 MAGNIMS centres were included. Data collection and analyses were conducted from 2019 to 2021. Inclusion criteria were: diagnosis of MOG-antibody disease; AQP4-neuromyelitis optica spectrum disorder and multiple sclerosis; brain and cord MRI at least 6 months from relapse; and Expanded Disability Status Scale (EDSS) score on the day of MRI. Brain white matter T2 lesions, T1-hypointense lesions, cortical and cord lesions were identified. Random forest models were constructed to classify patients as MOG-antibody disease/AQP4-neuromyelitis optica spectrum disorder/multiple sclerosis; a leave one out cross-validation procedure assessed the performance of the models. Based on the best discriminators between diseases, we proposed a guide to target investigations for MOG-antibody disease. One hundred and sixty-two patients with MOG-antibody disease [99 females, mean age: 41 (±14) years, median EDSS: 2 (0–7.5)], 162 with AQP4-neuromyelitis optica spectrum disorder [132 females, mean age: 51 (±14) years, median EDSS: 3.5 (0–8)], 189 with multiple sclerosis (132 females, mean age: 40 (±10) years, median EDSS: 2 (0–8)] and 152 healthy controls (91 females) were studied. In young patients (

Published
2023
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2. Real-world application of the 2022 diagnostic criteria for first-ever episode of optic neuritis.

Author

Terrim, Sara, Silva, Guilherme Diogo, de Sá e Benevides Falcao, Fernando Cavalcanti, dos Reis Pereira, Clarissa, de Souza Andrade Benassi, Thais, Fortini, Ida, Gonçalves, Marcia Rubia Rodrigues, Castro, Luiz Henrique Martins, Comerlatti, Luiz Roberto, de Medeiros Rimkus, Carolina, Adoni, Tarso, Pereira, Samira Luisa Apostolos, Monteiro, Mário Luiz, and Callegaro, Dagoberto

Subjects
*OPTIC neuritis, *NEURITIS, *DIFFERENTIAL diagnosis
Abstract

Optic neuritis (ON) admits diverse differential diagnoses. Petzold proposed diagnostic criteria for ON in 2022, although real-world application of these criteria is missing. We conducted a retrospective review of patients with ON. We classified patients into definite or possible ON, and into groups A (typical neuritis), B (painless), or C (binocular) and estimated the frequency of etiologies for each group. We included 77 patients, with 62% definite and 38% possible ON. CRION and NMOSD-AQP4 negative-ON were less commonly seen in definite ON. Application of the 2022 criteria revealed a lower-than-expected frequency of definite ON, particularly for seronegative non-MS causes. • Optic neuritis diagnostic criteria 2022 may have higher sensitivity for typical ON. • Non-MS seronegative ON may be underrepresented by diagnostic criteria. • Access to biomarkers may be an obstacle for diagnosis of ON in low-income scenarios. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Primary angiitis of the central nervous system as a mimic of multiple sclerosis: A case report.

Author

de Souza Tieppo, Eduardo Macedo, da Silva, Tomás Fraga Ferreira, de Araujo, Roger Santana, Silva, Guilherme Diogo, Paes, Vitor Ribeiro, de Medeiros Rimkus, Carolina, Tinone, Gisela, Pereira, Samira Apóstolos, and Callegaro, Dagoberto

Subjects
*CENTRAL nervous system, *MULTIPLE sclerosis, *VASCULITIS, *MAGNETIC resonance imaging, *DIFFERENTIAL diagnosis
Abstract

Primary angiitis of the central nervous system is a rare inflammatory vasculopathy and it is a difficult diagnosis to make because of its kaleidoscopic presentation and its multiple mimics, including multiple sclerosis. A 21-year-old men presented a four-year history of progressive gait deterioration. Magnetic resonance imaging of the brain and spine showed hyperintense round-shaped lesions on T2 images, many with contrast enhancement, in supra/infratentorial and spinal segments. He received treatment for multiple sclerosis but presented clinical worsening, and follow-up neuroimaging showed persistent contrast enhancement lesions and a cerebellar hematoma. Brain biopsy was performed and demonstrated inflammatory infiltrations in blood vessels. The patient received 6 monthly schedules of 5 g methylprednisolone and 1 g cyclophosphamide with clinical stabilization. Our patient presented a primary angiitis central nervous system according to the Birnbaum and Hellmann proposed criteria. This case reinforces the importance of advancing the differential diagnosis of patients that present red flags in brain neuroimaging. The presence of the micro/macrobleeds and persistent contrast enhancing lesions should raise the suspicion of vasculitis in the differential diagnosis of multiple sclerosis. [ABSTRACT FROM AUTHOR]

Published
2022
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