1. Tumor necrosis factor-α enhances IL-15-induced natural killer cell differentiation
- Author
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Lee, Jiwon, Lee, Suk Hyung, Shin, Nara, Jeong, Mira, Kim, Mi Sun, Kim, Mi Jeong, Yoon, Suk Ran, Chung, Jin Woong, Kim, Tae-Don, and Choi, Inpyo
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TUMOR necrosis factors , *INTERLEUKINS , *KILLER cells , *MOLECULAR cell differentiation , *NF-kappa B , *GENE expression , *MESSENGER RNA - Abstract
Abstract: The differentiation of natural killer (NK) cells is regulated by various factors including soluble growth factors and transcription factors. Here, we have demonstrated that tumor necrosis factor-α (TNF-α) is a positive regulator of NK cell differentiation. TNF-α augmented the IL-15-induced expression of NK1.1 and CD122 in mature NK cells, and TNF-α alone also induced NK cell maturation as well as IL-15. TNF-α also increased IFN-γ production in NK cells in the presence of IL-15. Meanwhile, mRNA expression of several transcription factors, including T-bet and GATA-3, was increased by the addition of TNF-α and IL-15. In addition, TNF-α increased nuclear factor-kappa B (NF-κB) activity in NK cells and inhibition of NF-κB impeded TNF-α-enhanced NK cell maturation. Overall, these data suggest that TNF-α significantly increased IL-15-driven NK cell differentiation by increasing the expression of transcription factors that play crucial roles in NK cell maturation and inducing the NF-κB activity. [Copyright &y& Elsevier]
- Published
- 2009
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