1. Diffuse alveolar hemorrhage in a healthy stem cell donor following administration of granulocyte colony – stimulating factor
- Author
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Rottem Kuint, Yotam Kolben, Avraham Abutbul, Barhoum Barhoum, and Fares Darawshy
- Subjects
Adult ,Lung Diseases ,Pathology ,medicine.medical_specialty ,Filgrastim ,Side effect ,Immunology ,Hemorrhage ,Granulocyte ,medicine ,Humans ,Immunology and Allergy ,Adverse effect ,Bone pain ,Pharmacology ,business.industry ,Hematopoietic Stem Cell Transplantation ,Diffuse alveolar hemorrhage ,Hematopoietic Stem Cell Mobilization ,Tissue Donors ,Granulocyte colony-stimulating factor ,medicine.anatomical_structure ,Stem cell donor ,Female ,medicine.symptom ,Stem cell ,business - Abstract
Background Granulocyte colony - stimulating factor (G-CSF) is frequently used in healthy adults prior to stem cell donation in order to mobilize stem cells to peripheral blood. Adverse events of G-CSF occur in about 30% and mainly include bone pain, fatigue, and headache. Pulmonary adverse events are rare. Case presentation Here, we describe a case of a healthy donor who developed diffuse alveolar hemorrhage after G-CSF administration. We suggest the underlying mechanism of this injury. Conclusion Diffuse alveolar hemorrhage can occur following G-CSF administration. Treating physicians should be aware of this infrequent but often life-threatening pulmonary side effect of G-CSF.
- Published
- 2021
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