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Your search keyword '"22q11 microdeletion syndrome"' showing total 2 results
Start Over Descriptor "22q11 microdeletion syndrome" Topic digeorge syndrome
2 results on '"22q11 microdeletion syndrome"'

1. Evidence of the impact of visuo-spatial processing on magnitude representation in 22q11.2 microdeletion syndrome.

Author

Attout L, Noël MP, Vossius L, and Rousselle L

Subjects
Adolescent, Child, Child, Preschool, Female, Humans, Judgment, Male, Memory, Short-Term, Neuropsychological Tests, Young Adult, DiGeorge Syndrome psychology, Mathematical Concepts, Space Perception, Spatial Processing, Visual Perception
Abstract

The influence of visuo-spatial skills on numerical magnitude processing is the subject of a long-standing debate. As most of the numerical and non-numerical magnitude abilities underpinning mathematical development are visual by nature, they are often assessed in the visual modality, thereby confusing visuo-spatial and numerical processing. In order to assess the influence of visuo-spatial processing on numerical magnitude representation, we examined magnitude processing in patients with 22q11.2 deletion syndrome (22q11DS), a genetic condition characterized by a cognitive profile with a relative weakness in visuo-spatial abilities but with preserved verbal abilities. Twenty-seven participants with 22q11DS were compared to two control groups (one matched on verbal intelligence and the other on visuo-spatial abilities) on several magnitude comparison tasks each with different visuo-spatial processing requirements. Our results showed that participants with 22q11DS present a consistent pattern of impairment in magnitude comparison tasks requiring the processing of visuo-spatial dimensions: comparison of lengths and collections. In contrast, their performance did not differ from the control groups in a visual task with no spatial processing requirement (i.e. numerical comparison of flashed dot sequences) or in auditory tasks (i.e., duration comparison and numerical comparison of sound sequences). Finally, a specific deficit of enumeration processes was observed in the subitizing range. Taken together, these results show that deficits in magnitude can occur as a consequence of a visuo-spatial deficit. This highlights the influence of the nature of the tasks selected to assess magnitude representation., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Published
2017
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2. Optimising immunisation in children with 22q11 microdeletion

Author

Vinita Prasad, Helen Heussler, Julia E Clark, Kahn Preece, Sophie C H Wen, Vanil Varghese, and Angela Berkhout

Subjects
velo-cardiofacial syndrome, 0301 basic medicine, lcsh:Immunologic diseases. Allergy, Pediatrics, medicine.medical_specialty, business.industry, lcsh:RM1-950, immunisation, medicine.disease, 22q11 microdeletion syndrome, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, lcsh:Therapeutics. Pharmacology, 030225 pediatrics, DiGeorge syndrome, medicine, 22q11 microdeletion, business, lcsh:RC581-607, Immunodeficiency, Original Research
Abstract

Background: The condition known as 22q11 microdeletion syndrome has a broad phenotypic spectrum, with many affected individuals experiencing mild-to-moderate immunodeficiency. Currently, there are significant variations in live vaccine practices and immunological testing prior to live vaccine administration due to safety concerns and limited established guidelines. Methods: Queensland Children’s Hospital (QCH) Child Development Unit, offers a state-wide 22q11 microdeletion clinic. This is a retrospective single-centre review, capturing the majority of children with 22q11 microdeletion in Queensland, Australia. We describe the live vaccination status of 134 children, age 0 to 18 years under our care between 2000 and 2018, adverse events following immunisation (AEFI) and the proportion of children who received additional pneumococcal coverage. An immunological investigation pathway prior to live vaccine administration is proposed. Results: Of the 134 children, 124 were eligible for live vaccinations as per the Australian National Immunisation Program: 82% had received dose one of measles, mumps and rubella (MMR) vaccine, 77% had completed MMR dose two and 66% had completed varicella immunisation. There were no AEFI notifications reported. Of the total sample of children, 18% received a fourth dose of conjugate pneumococcal vaccine (Prevenar 7 or 13) and 16% received a dose of Pneumovax 23 from 4 years of age. Immunology workup practices were demonstrated to vary widely prior to live vaccine administration. Most patients’ immune profiles were consistent with mild-to-moderate immunodeficiency. Conclusion: We propose an immunological investigation and vaccination pathway with the aim of providing guidance and consistency to clinicians caring for children with 22q11 microdeletion.

Published
2020

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