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4 results on '"Barrucand L"'

1. Carnitine supplementation in diphtheria.

Author

Ramos AC, Barrucand L, Elias PR, Pimentel AM, and Pires VR

Subjects
Brazil epidemiology, Child, Child, Preschool, Diphtheria complications, Female, Humans, Incidence, Infant, Male, Myocarditis etiology, Myocarditis mortality, Carnitine therapeutic use, Diphtheria drug therapy
Abstract

We studied the effect of carnitine supplementation in patients with diphtheria. Six hundred and twenty five children of diphtheria received either DL-carnitine (100 mg/kg/day in two divided doses orally for four days), or no carnitine, in addition to the routine treatment for diphtheria. The patients receiving carnitine (n = 327) and controls (n = 298) were matched for age, sex, duration of symptoms, grade of toxemia and immunization status. Patients receiving carnitine showed a significant reduction in incidence of myocarditis as compared to controls (p = 0.001). Cases with myocarditis receiving carnitine therapy showed a significant reduction in mortality as compared to controls (p < 0.001). In view of a significant decline in incidence and mortality of myocarditis in cases of diphtheria, we recommended that all cases with diphtheria should receive carnitine supplementation.

Published
1992

2. The protective effect of carnitine in human diphtheric myocarditis.

Author

Ramos AC, Elias PR, Barrucand L, and Da Silva JA

Subjects
Adolescent, Carnitine metabolism, Child, Child, Preschool, Creatine Kinase metabolism, Diphtheria metabolism, Electrocardiography, Female, Heart Failure prevention & control, Humans, Infant, Isoenzymes, Male, Myocarditis etiology, Myocarditis metabolism, Myocardium enzymology, Carnitine therapeutic use, Diphtheria drug therapy, Myocarditis drug therapy
Abstract

Carnitine, an important cofactor in the transport of fatty acids to the interior of cell mitochondria, is depleted in myocardial tissue of guinea pigs submitted to diphtheric toxin administration. Mortality rates were reduced in these animals by supplying exogenous amounts of carnitine. The accumulation of fatty acids in the cytoplasm of human heart cells reported in cases of diphtheria suggests that carnitine might possibly be depleted in human myocardium as well. For the purpose of studying the effect of carnitine administration, 132 diphtheric patients were randomly divided into two groups, one of them (carnitine-treated group, n = 73) receiving DL-carnitine, 100 mg/kg/day during 4 days after admission, in addition to routine treatment, which was prescribed for this and the control group (n = 59). The presence of myocardial damage was evaluated by clinical, electrocardiographic, radiological, and enzymatic criteria. Carnitine administration resulted in decreased incidence of heart failure (P = 0.0475), of pacemaker implants (P = 0.0256), and of lethality indexes due to myocarditis (P = 0.013). We suggest that carnitine can play an important role in the treatment of diphtheric patients.

Published
1984
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4. The protective effect of carnitine in human diphtheric myocarditis

Author

J.A.R. da Silva, P R Elias, A C Ramos, and Barrucand L

Subjects
Male, medicine.medical_specialty, Myocarditis, Adolescent, Cell, Biology, Mitochondrion, medicine.disease_cause, Electrocardiography, Internal medicine, Carnitine, medicine, Humans, Child, Creatine Kinase, chemistry.chemical_classification, Heart Failure, Toxin, Diphtheria, Myocardium, Infant, medicine.disease, Isoenzymes, Enzyme, medicine.anatomical_structure, Endocrinology, chemistry, Heart failure, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, medicine.drug
Abstract

Carnitine, an important cofactor in the transport of fatty acids to the interior of cell mitochondria, is depleted in myocardial tissue of guinea pigs submitted to diphtheric toxin administration. Mortality rates were reduced in these animals by supplying exogenous amounts of carnitine. The accumulation of fatty acids in the cytoplasm of human heart cells reported in cases of diphtheria suggests that carnitine might possibly be depleted in human myocardium as well. For the purpose of studying the effect of carnitine administration, 132 diphtheric patients were randomly divided into two groups, one of them (carnitine-treated group, n = 73) receiving DL-carnitine, 100 mg/kg/day during 4 days after admission, in addition to routine treatment, which was prescribed for this and the control group (n = 59). The presence of myocardial damage was evaluated by clinical, electrocardiographic, radiological, and enzymatic criteria. Carnitine administration resulted in decreased incidence of heart failure (P = 0.0475), of pacemaker implants (P = 0.0256), and of lethality indexes due to myocarditis (P = 0.013). We suggest that carnitine can play an important role in the treatment of diphtheric patients.

Published
1984

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