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Start Over Author "Simeone, Jason C." Topic direct medical costs
3 results on '"Simeone, Jason C."'

2. Burden of Pertussis in Individuals with a Diagnosis of Asthma: A Retrospective Database Study in England

Author

Bhavsar, Amit, Aris, Emmanuel, Harrington, Lauriane, Simeone, Jason C, Ramond, Anna, Lambrelli, Dimitra, Papi, Alberto, Boulet, Louis-Philippe, Meszaros, Kinga, Jamet, Nicolas, Sergerie, Yan, and Mukherjee, Piyali

Subjects
Pulmonary and Respiratory Medicine, health care resource utilization, pertussis, Journal of Asthma and Allergy, incidence, Socio-culturale, Immunology and Allergy, direct medical costs, Asthma, direct medical costs, health care resource utilization, incidence, pertussis, asthma, respiratory tract diseases, Original Research
Abstract

Amit Bhavsar,1 Emmanuel Aris,2 Lauriane Harrington,3 Jason C Simeone,4 Anna Ramond,5 Dimitra Lambrelli,5 Alberto Papi,6 Louis-Philippe Boulet,7 Kinga Meszaros,8 Nicolas Jamet,8 Yan Sergerie,3 Piyali Mukherjee3 1Europe Medical Affairs, GSK, Wavre, Belgium; 2Real-World Analytics, GSK, Wavre, Belgium; 3Global Medical Affairs, GSK, Wavre, Belgium; 4Real-World Evidence, Evidera Inc., Waltham, MA, USA; 5Real-World Evidence, Evidera Ltd, London, UK; 6Respiratory Medicine, University of Ferrara, Ferrara, Italy; 7Department of Medicine, Laval University, Quebec City, Quebec, Canada; 8Value Evidence and Outcomes, GSK, Wavre, BelgiumCorrespondence: Amit Bhavsar Tel +32 10 85 51 11Email amit.b.bhavsar@gsk.comPurpose: The impact of pertussis in individuals with asthma is not fully understood. We estimated the incidence, health care resource utilization (HCRU), and direct medical costs (DMC) of pertussis in patients with asthma.Patients and Methods: In this retrospective cohort study, the incidence rate of pertussis (identified using diagnostic codes) among individuals aged ≥ 50 years with an asthma diagnosis was assessed during 2009– 2018 using Clinical Practice Research Datalink and Hospital Episode Statistics databases. HCRU and DMC were compared – between patients with diagnoses of asthma and pertussis (asthma+/pertussis+) and propensity score-matched patients with a diagnosis of asthma without pertussis (asthma+/pertussis–) – in the months around the pertussis diagnosis (– 6 to +11).Results: Among 687,105 individuals, 346 had a reported pertussis event (incidence rate: 9.6/100,000 person-years of follow-up; 95% confidence interval: 8.6– 10.7). HCRU and DMC were assessed among 314 asthma+/pertussis+ patients and 1256 matched asthma+/pertussis– controls. Baseline HCRU was similar in both cohorts, but increases were observed in the asthma+/pertussis+ cohort from – 6 to – 1 month before to 2– 5 months after diagnosis. Rates of accident and emergency visits, general practitioner (GP)/nurse visits, and GP prescriptions were 4.3-, 3.1-, and 1.3-fold, respectively, in the asthma+/pertussis+ vs asthma+/pertussis– cohorts during the month before diagnosis; GP/nurse visit rates were 2.0- and 1.2-fold during 0– 2 and 2– 5 months after diagnosis, respectively (all p< 0.001). DMC was 1.9- and 1.6-fold during the month before and 2 months from diagnosis, respectively, in the asthma+/pertussis+ vs asthma+/pertussis– cohorts (both p< 0.001). During months – 1 to +11, DMC in the asthma+/pertussis+ cohort was £ 370 higher than in the asthma+/pertussis– controls.Conclusion: A pertussis diagnosis among adults aged ≥ 50 years with asthma resulted in significant increases in HCRU and DMC across several months around diagnosis, suggesting lengthy diagnosis times and highlighting the need for prevention strategies.Keywords: asthma, direct medical costs, health care resource utilization, incidence, pertussis

Published
2022

3. Burden of Pertussis in COPD: A Retrospective Database Study in England.

Author

Aris, Emmanuel, Harrington, Lauriane, Bhavsar, Amit, Simeone, Jason C., Ramond, Anna, Papi, Alberto, Vogelmeier, Claus F., Meszaros, Kinga, Lambrelli, Dimitra, and Mukherjee, Piyali

Subjects
WHOOPING cough, HOSPITAL statistics, OBSTRUCTIVE lung diseases, MEDICAL care use, NUMERIC databases
Abstract

Chronic obstructive pulmonary disease (COPD) may increase the risk and severity of pertussis infection. Health care resource utilization (HCRU) and direct medical costs (DMC) of treating pertussis among patients with COPD are unknown. Reported incidence of pertussis among individuals aged ≥ 50 years with COPD was assessed in Clinical Practice Research Datalink and Hospital Episode Statistics databases during 2009–2018 using a retrospective cohort design. HCRU and DMC from the National Health Service perspective were compared between patients with COPD and pertussis and propensity score-matched patients with COPD without pertussis. Seventy-eight new pertussis events were identified among 387 086 patients with COPD aged ≥ 50 years (incidence rate: 4.73; 95% confidence interval 3.74–5.91 per 100 000 person-years). HCRU and DMC were assessed among 67 patients with COPD and pertussis and 267 matched controls. During the month before the pertussis diagnosis, the rates of general practitioner (GP)/nurse visits (4289 vs. 1774 per 100 patient-years) and accident and emergency visits (182 vs. 18 per 100 patient-years) were higher in the pertussis cohort; GP/nurse visits (2935 vs. 1705 per 100 patient-years) were also higher during the following 2 months (all p < 0.001). During the month before the pertussis diagnosis, annualized per-patient total DMC were £2012 higher in the pertussis cohort (£3729 vs. £1717; p < 0.001); during the following 2 months, they were £2407 higher (£5498 vs. £3091; p < 0.001). In conclusion, a pertussis episode among individuals with COPD resulted in significant increases in HCRU and DMC around the pertussis event. [ABSTRACT FROM AUTHOR]

Published
2021
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