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1. Constipation Predicts Cognitive Decline in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-up and Comparison with a Control Group

Author

Marina Cosgaya, Jose M. Paz González, Esther Cubo, Maria G. Alonso Losada, Nuria López Ariztegui, Isabel González Aramburu, Carmen Borrué, Lydia López Manzanares, Jaime Kulisevsky, Iria Cabo, Julio Dotor García-Soto, Pau Pastor, Carlos Cores Bartolomé, Nuria Caballol, Jessica González Ardura, Lucía García Roca, Berta Solano Vila, Luis M. López Díaz L, Víctor Puente, Pablo Martinez-Martin, Juan García Caldentey, Javier Rúiz Martínez, Lydia Vela, Cristina Martínez Miró, Itziar Gastón, Lucía Naya Ríos, Francisco Carrillo Padilla, Ruben Alonso Redondo, Darrian McAfee, Juan C. Martínez Castrillo, Ines Legarda, Silvia Jesús, Carlos Ordás, Víctor Nogueira, Marta Blázquez Estrada, Oriol de Fábregues, Miquel Aguilar, Hector Canfield, Manuel Seijo, Teresa de Deus Fonticoba, Jorge Hernández Vara, Maria A. Ávila Rivera, Pablo Mir, Pilar Sánchez Alonso, Diego Santos García, Lluis Planellas, Caridad Valero, Monica M. Kurtis, Víctor Gómez Mayordomo, Sonia Escalante, and María Álvarez Sauco

Subjects
medicine.medical_specialty, impairment, Constipation, Parkinson's disease, Non-motor symptoms, Disease, Cellular and Molecular Neuroscience, Cognition, Rating scale, Internal medicine, Cognitive Changes, Medicine, Humans, Cognitive Dysfunction, Cognitive decline, business.industry, Parkinson Disease, constipation, medicine.disease, Control Groups, non-motor symptoms, Impairment, Cohort, Parkinson’s disease, Neurology (clinical), medicine.symptom, business, Follow-Up Studies
Abstract

[Background] Constipation has been linked to cognitive impairment development in Parkinson’s disease (PD). Objective:Our aim was to analyze cognitive changes observed in PD patients and controls from a Spanish cohort with regards to the presence or not of constipation. Methods:PD patients and controls recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017 were followed-up during 2 years. The change in cognitive status from baseline (V0) to 2-year follow-up was assessed with the PD-CRS (Parkinson’s Disease Cognitive Rating Scale). Subjects with a score ≥1 on item 21 of the NMSS (Non-Motor Symptoms Scale) at baseline (V0) were considered as “with constipation”. Regression analyses were applied for determining the contribution of constipation in cognitive changes., [Results] At V0, 39.7% (198/499) of PD patients presented constipation compared to 11.4% of controls (14/123) (p, [Conclusion] Constipation is associated with cognitive decline in PD patients but not in controls.

Published
2022

2. Falls Predict Acute Hospitalization in Parkinson's Disease

Author

Ines Legarda, Diego Santos García, Iria Cabo, Carmen M. Labandeira, Isabel González Aramburu, Juan C. Martínez Castrillo, Esther Cubo, Teresa de Deus Fonticoba, Bárbara Vives, Marta Blázquez Estrada, Lydia Vela, Ester Suárez Castro, Nuria Caballol, Juan García Caldentey, Pablo Mir, Pau Pastor, Maria José Catalán, Maria G. Alonso Losada, Nuria López Ariztegui, Marina Cosgaya, Carmen Borrué, Berta Solano Vila, Caridad Valero, Itziar Gastón, Jessica González Ardura, Carlos Ordás, Ioana Croitoru, Noemí Bernardo, Víctor Nogueira, Jon Infante, Manuel Seijo, Javier Miranda, Jaime Kulisevsky, Manuel Menéndez González, Silvia Jesús, Cristina Prieto, María Álvarez Sauco, Carlos Cores, Javier Rúiz Martínez, Luis Manuel López Díaz, Jorge Hernández Vara, Maria A. Ávila Rivera, Pablo Martinez-Martin, María José Martí, Monica M. Kurtis, Víctor Gómez Mayordomo, Sonia Escalante, Oriol de Fábregues, Pilar Sánchez Alonso, Víctor Puente, Lydia López Manzanares, Jose Manuel García Moreno, Francisco Carrillo Padilla, Mabel Morales-Casado, Institut Català de la Salut, [Santos García D, Cores C] Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain. [de Deus Fonticoba T, Suárez Castro E] Complexo Hospitalario Universitario de Ferrol, A Coruña, Spain. [Hernández Vara J] Departament de Neurologia i Recerca de Malalties Neurodegeneratives. Campus Universitari de la Vall D'Hebron, Barcelona, Spain. [Jesús S, Mir P] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, CSIC, CIBERNED, Universidad de Sevilla, Sevilla, Spain. [Solano Vila B] Institut d'Assistència Sanitària, Institut Català de la Salut, Salt, Spain, Institut d'Assistència Sanitària, and Universidad de Cantabria

Subjects
Levodopa, medicine.medical_specialty, Acute hospitalization, Parkinson's disease, Organic Chemicals::Amines::Catecholamines::Dihydroxyphenylalanine::Levodopa [CHEMICALS AND DRUGS], Non-motor symptoms, Disease, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson [ENFERMEDADES], Internal medicine, Dopa, medicine, Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], 030212 general & internal medicine, Parkinson, Malaltia de, Predictors, business.industry, Proportional hazards model, Models de riscos proporcionals de Cox, Hazard ratio, compuestos orgánicos::aminas::catecolaminas::dihidroxifenilalanina::levodopa [COMPUESTOS QUÍMICOS Y DROGAS], Nervous System Diseases::Nervous System Diseases::Nervous System Diseases::Neurodegenerative Diseases::Parkinson Disease [DISEASES], medicine.disease, Dysphagia, Hospitalization, Cohort, Parkinson’s disease, Falls, Neurology (clinical), medicine.symptom, business, técnicas de investigación::métodos epidemiológicos::estadística como asunto::modelos estadísticos::modelos de riesgos proporcionales [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], 030217 neurology & neurosurgery, medicine.drug
Abstract

Malaltia de Parkinson; Levodopa; Factors de risc Enfermedad de Parkinson; Levodopa; Factores de riesgo Parkinson Disease; Levodopa; Risk Factors Background:There is a need for identifying risk factors for hospitalization in Parkinson’s disease (PD) and also interventions to reduce acute hospital admission. Objective:To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort.Methods:PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit.Results:Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065–5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319–6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757–8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124–4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080–8.322; p = 0.035) was an independent predictor of AH. Conclusion:Falls is an independent predictor of AH in PD patients

Published
2021

3. Mood in Parkinson's disease: From early- to late-stage disease

Author

Ángel Aneiros, Ardura J. González, Nuria Caballol, Jurczynska C. Prieto, C Valero, Víctor Nogueira, Silvia Jesús, Pablo Mir, Lluís Planellas, Padilla F. Carrillo, Caldente J. García, I. Legarda, Losada M. G. Alonso, Itziar Gastón, Moreno J. M. García, Miquel Aguilar, Aymerich L. Valdés, Alonso P. Sánchez, Bartolome C. Cores, Vila B. Solano, Darrian McAfee, Lydia Vela, Aramburu I. González, Pau Pastor, Esther Cubo, Castro E. Suárez, Víctor Puente, Ariztegui N. López, Díaz L. López, Castrillo J. C. Martínez, Fonticoba T. De Deus, Diego Santos-García, Rivera M. A. Ávila, Jaime Kulisevsky, C Borrué, Monica M. Kurtis, S Escalante, Vara J. Hernández, Sauco M. Álvarez, Marina Cosgaya, Manzanares L. López, M Seijo, Iria Cabo, Estrada M. Blázquez, Catalán M. José, Martínez J. Rúiz, and Oriol de Fábregues-Boixar

Subjects
Male, medicine.medical_specialty, Parkinson's disease, mood, Disease, Group B, s disease, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Internal medicine, Surveys and Questionnaires, Linear regression, Medicine, Humans, Depression (differential diagnoses), Aged, 030214 geriatrics, business.industry, Parkinson Disease, Parkinson&apos, medicine.disease, Health Surveys, Psychiatry and Mental health, Mood, Cross-Sectional Studies, quality of life, Cohort, depression, Quality of Life, Female, Geriatrics and Gerontology, disease duration, business
Abstract

Background Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. Methods PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross-sectional study. Three groups were defined: = 10 years (Group C). Analysis with well-planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory-II [BDI-II] as dependent variable), to health-related QoL (39-item Parkinson's Disease Questionnaire [PDQ-39SI] as dependent variable) and to global QoL (European Health Interview Survey - Quality of Life Eight-Item Index [EUROHIS-QOL8] as dependent variable). Results Six hundred and sixty-three PD patients (62.6 +/- 8.9 years old, 59.6% males) were included: Group A, 50.1% (n = 332); Group B, 33.3% (n = 221) and Group C, 16.6% (n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) (p = 0.729). However, the unique percent variance of PDQ-39SI and EUROHIS-QOL8 explained by BDI-II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS-QOL8 total score provided the highest unique contribution to mood (16.8%). Conclusions Although depression-type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.

Published
2021

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