1. Increased incidence rates of positive blood cultures shortly after chemotherapy compared to radiotherapy among individuals treated for solid malignant tumours.
- Author
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Roen, Ashley, Terrones, Cynthia, Bannister, Wendy, Helleberg, Marie, Andersen, Michael Asger, Niemann, Carsten Utoft, Daugaard, Gedske, Specht, Lena, Mocroft, Amanda, Reekie, Joanne, and Lundgren, Jens
- Subjects
TUMOR treatment ,BLOOD ,ESCHERICHIA coli ,CELL culture ,COMMUNICABLE diseases ,CONFIDENCE intervals ,CANCER chemotherapy ,TIME ,MORTALITY ,DISEASE incidence ,IMMUNOSUPPRESSION ,COMPARATIVE studies ,TREATMENT effectiveness ,RESEARCH funding ,DESCRIPTIVE statistics ,RADIOTHERAPY ,DATA analysis software ,ONCOLOGY ,DISEASE risk factors - Abstract
Background: Cancer treatments suppress immune function and are associated with increased risk of infections, but the overall burden of serious infectious diseases in treated patients has not been clearly elucidated. Methods: All patients treated for solid malignant tumours with radiotherapy (RT) and/or standard first-line chemotherapy (C) at the Department of Oncology at Rigshospitalet between 01/1/2010 and 31/12/2016 were included. Patients were followed from treatment initiation until the first of new cancer treatment, 1 year after treatment initiation, end of follow-up or death. Incidence rates (IR) of positive blood culture (PBC) per 1000 person-years follow-up (PYFU) were calculated. Findings: 12,433 individuals were included, 3582 (29%), 6349 (51%), and 2502 (20%) treated with RT, C, or both RT & C, respectively, contributing 8182 PYFU. 429 (3%) individuals experienced 502 unique episodes of PBC, incidence rate (95% CI) 52.43 (47.7, 57.6) per 1000 PYFU. The 30-day mortality rate after PBC was 24% independent of treatment modality. Adjusted incidence rate ratios in the first 3 months (95% CI) after PBC significantly varied by treatment: 2.89 (1.83, 4.55) and 2.52 (1.53, 4.14) for C and RT & C compared to RT. Escherichia coli (n = 127, 25%) was the top microorganism identified. Interpretation: PBCs are not common, but when they occur, mortality is high. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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