1. gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir.
- Author
-
Shah, Ruchi, Sharma, Varun, Singh, Hemender, Sharma, Indu, Bhat, Gulzar, Shah, Idrees, Iqbal, Beenish, Rafiq, Rumisa, Nissa, Najma, Muzaffar, Mansha, Rasool, Malik, Lone, Ghulam, Kaul, Sandeep, Lone, Mohd, Rai, Ekta, Dar, Nazir, Sharma, Swarkar, Bhat, Gulzar Ahmed, Shah, Idrees Ayoub, and Rasool, Malik Tariq
- Subjects
CANCER susceptibility ,ASIANS ,ODDS ratio ,CANCER genes ,CHI-squared test ,ESOPHAGEAL motility ,ESOPHAGEAL cancer ,NERVE tissue proteins ,SEQUENCE analysis ,GENETIC polymorphisms ,CASE-control method ,PROGNOSIS ,MEMBRANE glycoproteins ,DISEASE susceptibility ,ESOPHAGEAL tumors ,LONGITUDINAL method - Abstract
Background: Leucine-rich repeat and fibronectin type 2 gene (LRFN2) variant rs2494938 has recently been found associated with esophageal cancer in a genome-wide association study in an Asian population. However, this association has not been replicated in any Indian population despite high incidence of the disease.Materials and Methods: In the present case-control study, 166 cases and 459 controls were included. Taqman assay technique using real-time PCR was employed to investigate the association of the variant with esophageal cancer in the population of Jammu and Kashmir (J&K). The Hardy-Weinberg equilibrium for rs2494938 was assessed using the Chi-square test. The allele- and genotype-specific risk was estimated by odds ratio (OR) with 95% confidence interval (CI).Results: Variant rs2494938 was observed to be significantly associated with esophageal cancer with an allelic OR of 1.59 (1.23-2.04 at 95% CI, P = 0.0003).Conclusion: The study highlights LRFN2 as a candidate gene for esophageal cancer susceptibility in the population of J&K and calls for a detailed study with a large sample size and involving more ethnic groups of India. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF