1. An updated meta-analysis for association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer.
- Author
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Wen-Zhou Liu, Yu Sun, Xu Feng, Xiao-Han Bi, Tao Liu, Hua-Fu Zhou, Liu, Wen-Zhou, Sun, Yu, Feng, Xu, Bi, Xiao-Han, Liu, Tao, and Zhou, Hua-Fu
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LUNG cancer , *GLUTATHIONE , *META-analysis , *SINGLE nucleotide polymorphisms , *DISEASE susceptibility , *ALLELES , *COMPARATIVE studies , *GENETIC polymorphisms , *LUNG tumors , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *TRANSFERASES , *EVALUATION research - Abstract
Aim Of Study: The conclusions on the association between glutathione S-transferase P1 (GSTP1) gene polymorphism and lung cancer risk are still debated. This meta-analysis was performed to update the association between GSTP1 and the risk of lung cancer.Materials and Methods: The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method.Results: Fifty reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and lung cancer susceptibility. The association between GSTPI G allele/GG genotype and lung cancer risk was found in this meta-analysis (G allele: odds ratio [OR] = 1.08, 95% confidence interval [CI]: 1.02-1.14, P = 0.006; GG genotype: OR = 1.09, 95% CI: 1.00-1.18, P = 0.04). However, the AA genotype was not associated with the susceptibility of lung cancer.Conclusion: GSTP1 G allele/GG genotype is associated with the lung cancer susceptibility. [ABSTRACT FROM AUTHOR]- Published
- 2018
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