1. CCND1 rs9344 polymorphism is associated with the risk of hepatocellular carcinoma in Caucasian population.
- Author
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Wang, Da-dong, Duan, Wei-dong, Zhu, Zi-man, Tu, Yu-liang, Dou, Chun-qing, Han, Ming-ming, Zhang, Bao, Zhao, Wei, and Jiang, Kai
- Subjects
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GENETIC polymorphisms , *LIVER cancer , *ODDS ratio , *CONFIDENCE intervals , *ALLELES , *ASIANS , *COMPARATIVE studies , *DISEASE susceptibility , *GENETIC techniques , *HEPATOCELLULAR carcinoma , *LIVER tumors , *RESEARCH methodology , *MEDICAL cooperation , *META-analysis , *PROTEINS , *RESEARCH , *RISK assessment , *WHITE people , *EVALUATION research , *CASE-control method , *PUBLICATION bias - Abstract
Aims: Some studies investigated the association between CCND1 rs9344 polymorphism and hepatocellular carcinoma (HCC) risk. However, the results were inconclusive. Thus, we did a meta-analysis to determine this relationship.Materials and Methods: Relevant studies were systematically searched using the PubMed, CNKI, and EMBASE databases. The strength of the association was calculated with the odds ratio (OR) and respective 95% confidence intervals (Cis).Results: We investigated the association between CCND1 rs9344 polymorphism and HCC risk in the dominant models. The result of this meta-analysis showed that CCND1 rs9344 polymorphism did not significantly associated with HCC risk (OR = 1.09; 95% CI 0.88-1.34). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with HCC risk in Caucasians (OR = 1.55; 95% CI, 1.05-2.29). However, we did not find any significant association between this polymorphism and HCC risk in Asians (OR = 0.91; 95% CI, 0.71-1.18).Conclusions: This meta-analysis suggested that CCND1 rs9344 polymorphism might be associated with the risk of HCC among Caucasians. [ABSTRACT FROM AUTHOR]- Published
- 2018
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