1. Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review
- Author
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Giuditta Mannelli, Lara V. Comini, Andrea Sacchetto, Roberto Santoro, Giuseppe Spinelli, Pierluigi Bonomo, Isacco Desideri, Paolo Bossi, Ester Orlandi, Giammarco Alderotti, Alessandro Franchi, Annarita Palomba, Albino Eccher, Daniele Marchioni, Riccardo Nocini, Cesare Piazza, and Gabriele Molteni
- Subjects
Salvage Therapy ,Otorhinolaryngology ,salvage surgery ,salvage surgery outcomes ,Humans ,recurrent salivary cancer ,recurrent salivary tumors ,salivary cancer failure ,Neoplasm Recurrence, Local ,Salivary Gland Neoplasms ,Disease-Free Survival ,Retrospective Studies - Abstract
Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty-five patients underwent salvage surgery (20.1%) and their 5-year mortality rate, overall survival and disease-free survival were 35%, 70%, and 42%, respectively. RSCs are aggressive neoplasms with a high rate of distant metastases (28.9%). Salvage surgery can be considered in patients with limited local and/or regional recurrences, even in case of single distant relapse, appearing within the first 3 years of follow-up.
- Published
- 2022