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Your search keyword '"Motohiro Tamiya, MD"' showing total 2 results
Start Over Author "Motohiro Tamiya, MD" Topic diseases of the circulatory (cardiovascular) system
2 results on '"Motohiro Tamiya, MD"'

1. A Case of Lung Cancer with Very-Late-Onset Immune Checkpoint Inhibitor-Related MyocarditisNovel Teaching Points

Author

Tatsuya Nishikawa, MD, PhD, Motohiro Tamiya, MD, PhD, Keiko Ohta-Ogo, MD, PhD, Yoshihiko Ikeda, MD, PhD, Kinta Hatakeyama, MD, PhD, Keiichiro Honma, MD, PhD, Taku Yasui, MD, PhD, Wataru Shioyama, MD, PhD, Toru Oka, MD, PhD, Takako Inoue, MD, PhD, Toru Kumagai, MD, PhD, and Masashi Fujita, MD, PhD

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Immune checkpoint inhibitor (ICI)-related myocarditis has been reported to appear in the early phase after ICI initiation. Herein, we report the case of a 78-year-old man with non-small cell lung cancer. Pembrolizumab was introduced as first-line therapy. After 9 months, second-line therapy, including bevacizumab, was initiated. After another 7 months, echocardiography showed diffuse left ventricular dysfunction. Based on the histopathologic examination of the myocardium, the patient was diagnosed with ICI-related myocarditis. Initiation of prednisolone therapy improved cardiac function. This case of late-onset ICI-related myocarditis illustrates that endomyocardial biopsy can be useful in the differential diagnosis of cancer-related left ventricular dysfunction. Résumé: Il a été rapporté qu’une myocardite pouvait survenir peu après l’instauration d’un traitement par des inhibiteurs des points de contrôle immunitaire (ICI). Nous présentons le cas d’un homme de 78 ans atteint d’un cancer du poumon non à petites cellules. Le pembrolizumab a été administré comme traitement de première intention. Neuf mois plus tard, un traitement de deuxième intention par le bévacizumab a été instauré. Après sept autres mois, l’échocardiographie a montré une dysfonction ventriculaire gauche diffuse. À la suite des résultats de l’examen histopathologique du myocarde, une myocardite liée aux ICI a été diagnostiquée. L’instauration d’un traitement par la prednisolone a amélioré la fonction cardiaque du patient. Ce cas de myocardite tardive liée aux ICI montre l’utilité éventuelle de la biopsie de l’endomyocarde dans le diagnostic différentiel d’une dysfonction ventriculaire gauche liée au cancer.

Published
2022
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2. Cardiac Adverse Events in EGFR-Mutated Non-Small Cell Lung Cancer Treated With Osimertinib

Author

Kei Kunimasa, MD, PhD, Risa Kamada, MD, Toru Oka, MD, PhD, Makiko Oboshi, MD, PhD, Madoka Kimura, MD, Takako Inoue, MD, Motohiro Tamiya, MD, Tatsuya Nishikawa, MD, PhD, Taku Yasui, MD, PhD, Wataru Shioyama, MD, PhD, Kazumi Nishino, MD, PhD, Fumio Imamura, MD, PhD, Toru Kumagai, MD, PhD, and Masashi Fujita, MD, PhD

Subjects
cardiac adverse events, cardiac dysfunction, EGFR mutations, myocardial biopsy, non–small cell lung cancer, osimertinib, Diseases of the circulatory (Cardiovascular) system, RC666-701, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objectives: The purpose of this study was to assess osimertinib-associated cardiac adverse events (AEs) in a real-world setting, using a retrospective single-center cohort study in Japan. Background: Cases of osimertinib-associated cardiac AEs have been reported but remain poorly understood. Methods: A total of 123 cases of advanced non–small cell lung cancer (NSCLC) with confirmed EGFR mutations who received osimertinib monotherapy from 2014 to 2019 at the Osaka International Cancer Institute (Osaka, Japan) were evaluated. Cardiac AEs were defined according to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Changes in left ventricular ejection fraction (LVEF) and rates of cancer therapeutics-related cardiac dysfunction (CTRCD), defined as a ≥10 % absolute decline in LVEF from baseline to a value of

Published
2020
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