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Background: A community pharmacist is generally involved in the activities such as dispensing of drugs and medication aids, billing, patient counseling, and provision of pharmaceutical care. Even though there is huge scope to conduct research about all these aspects in India, community pharmacy-based research is found very rarely in literature. Aim: This study aims to assess dispensing pattern and economic aspects of antibiotics in a community pharmacy on an outpatient basis. Materials and Methods: A prospective, observational study was conducted in a community pharmacy of Pune city on outpatient basis. Patient demographics and antibiotics details with cost were obtained in a log book. Various average values and defined daily doses (DDD) were determined. Chi-square test was used to determine the association between different parameters. Results: A total of 460 patients were involved in the study. Important findings were average total cost of antibiotics – INR 61.42, highest total DDD – azithromycin (107.83 g), and highest antibiotic dispensed – amoxicillin + clavulanic acid (22.61%). The parameters, prescriber and duration, age and frequency, and prescriber and frequency showed statistically significant association (P < 0.05). Conclusion: This was one of the rare studies conducted in a community pharmacy setup on outpatient basis. Further studies are needed for better understanding and documentation of the data.