1. Oxidation of Disulfides to Taurine and Sulfanilic Acid Derivatives.
- Author
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Šála, Michal, Dejmek, Milan, Procházková, Eliška, Hřebabecký, Hubert, Rybáček, Jiří, Dračínský, Martin, Novák, Pavel, Rosenbergová, Šárka, Rosenberg, Ivan, and Nencka, Radim
- Subjects
CYCLOHEXANE ,NUCLEIC acids ,CARBOCYCLIC acids ,OLIGONUCLEOTIDES ,PHARMACEUTICAL chemistry - Abstract
Taurine (2-aminoethanesulfonic acid) is a representative substructure in biologically active compounds, but can raise difficulties in direct coupling reactions. In this study, the synthesis of taurine-derived sulfonic acids and analogous aromatic sulfonic acids was accomplished by a performic acid promoted oxidation of corresponding symmetrical disulfide precursors. In some of the products, the taurine or sulfanilic acid nitrogen atom is incorporated in a heterocyclic scaffold or part of a peptide bond in dipeptide mimetics. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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