1. Nucleosome deposition and DNA methylation may participate in the recognition of premature termination codon in nonsense-mediated mRNA decay.
- Author
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Niu DK and Cao JL
- Subjects
- 3' Untranslated Regions, Animals, Caenorhabditis elegans genetics, Caenorhabditis elegans metabolism, Drosophila melanogaster genetics, Drosophila melanogaster metabolism, Models, Genetic, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae metabolism, Signal Transduction genetics, Codon, Nonsense genetics, Codon, Nonsense metabolism, DNA Methylation genetics, Nucleosomes genetics, Nucleosomes metabolism, RNA Stability genetics
- Abstract
In non-mammalian eukaryotes, an abnormally long 3' untranslated region (UTR) is generally thought to be the definitive signal in the recognition of a premature termination codon (PTC) in nonsense-mediated mRNA decay (NMD). However, because the lengths of 3' UTRs in normal mRNAs are widely distributed, "abnormally long" is hard to define. Distinct peaks of nucleosome deposition and DNA methylation have recently been found at coding region boundaries. We propose that nucleosomes and DNA methylation just upstream of a normal stop codon are ideal indicators for the position of a normal stop codon and may thus serve as signals in PTC recognition., (Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
- Published
- 2010
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