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Keywords: blastematous; choroid plexus tumour; DNA methylation profiling; mesenchymal EN blastematous choroid plexus tumour DNA methylation profiling mesenchymal 1 3 3 02/03/22 20220215 NES 220215 INTRODUCTION Choroid plexus tumours are intraventricular neoplasms derived from the choroid plexus epithelium. (F) Black scale bars represent 500 m for panel (B) and 50 m for panels (C)-(E) gl DNA-methylation profiling (Illumina Methylation EPIC BeadChip) using the Heidelberg central nervous system (CNS) tumour classifier3 showed the case to be a "choroid plexus tumour, subclass paediatric B" (calibrated score 0.99), and the similarity with this molecular subgroup was further confirmed by t-SNE analysis (Figure 1F). The high similarity of the DNA methylation profile with choroid plexus tumours of the molecular subclass paediatric B is characteristic for malignant choroid plexus tumours and may suggest that the tumour secondarily acquired blastematous features. [Extracted from the article]