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Objective: To assess the occurrence of acute kidney injury (AKI) in dogs undergoing cardiac surgery under cardiopulmonary bypass (CPB) and explore associations between traditional and novel serum and urinary biomarkers. Design: Prospective cohort study conducted between July 2018 and April 2019. Setting: University teaching hospital. Animals: Nineteen dogs undergoing cardiac surgery under CPB with preoperative serum creatinine 1, T 2, T 3, and T 4). AKI was defined as an increase in serum creatinine ≥26.4 μmol/L (≥0.3 mg/dl) above baseline within 48 hours. Serum creatinine, C-reactive protein (CRP), symmetric dimethylarginine (SDMA), inosine, beta-aminoisobutyric acid (BAIB), urinary clusterin (uClus), and urinary cystatin B (uCysB) were measured. Data were log-transformed (log 10) when appropriate and assessed using linear mixed-effects models. Measurements and Main Results: AKI occurred in 3 of 19 dogs (15.8%, 95% confidence interval: 0.047–0.384). Inosine increased at T 2 (adjusted mean ± standard error: 53 ± 5.6) in all dogs, and then gradually decreased. Log 10uCysB increased at T 2 (2.3 ± 0.1) in all dogs and remained high. Log 10CRP and log 10uClus increased significantly at T 3 (1.9 ± 0.1 and 3.6 ± 0.1, respectively) in all dogs and remained increased. There was a significant positive association between serum creatinine and SDMA (P 10CRP and log 10uClus (P

ObjectiveTo evaluate the seasonality of canine tetanus in England.MethodsMedical records of a single referral hospital in England were reviewed. Dogs diagnosed with localized or generalized tetanus between January 2006 and June 2017 were studied.ResultsForty-nine cases were included. The prevalence of tetanus in England was significantly higher in the winter when compared with the summer (P=0.002) and autumn (P=0.024), with the highest number of cases recorded in February.ConclusionsThe prevalence of canine tetanus in England was significantly higher in winter months, especially in February.