Search

Objective: To evaluate refractive state outcomes following phacoemulsification and implantation of 3 different intraocular lenses (IOLs)., Animals: A prospective, randomized, controlled study was conducted on 43 client-owned dogs undergoing phacoemulsification with IOL implantation., Methods: Eyes were randomized to receive either an-vision Fo-X (n = 26), an-vision MD8 (18), or I-MED I-LENS (24) IOL. Refraction was measured 1 week, 1 month, and 3 months postoperatively using streak retinoscopy by 2 examiners masked to each other's results., Results: Postoperative refractive outcomes were highly correlated and not significantly different between 2 examiners for all time points (r = 0.97, 0.98, and 1.00; P = .76, .94, and .98, respectively). One week postoperatively, the refractive errors (mean ± SD) for Fo-X, MD8, and I-LENS were -0.14 ± 2.02 diopters (D), 0.97 ± 2.01 D, and 0.15 ± 2.55 D, respectively. One month postoperatively, the refractive errors were 0.35 ± 2.04 D, 0.06 ± 2.41 D, and -0.82 ± 2.20 D, respectively. Three months postoperatively, the refractive errors were -0.16 ± 2.67 D, 1.60 ± 2.99 D, and 0.59 ± 1.51 D, respectively. There were no significant differences in refractive error outcomes between Fo-X, MD8, and I-LENS at 1 week, 1 month, and 3 months postoperatively (P = .16; F(df=2,66)- = 1.89). However, the Fo-X was the only IOL to yield nearly emmetropic outcomes (±0.50 D) at all 3 time points., Clinical Relevance: The postoperative refractive states of dogs were not statistically different when comparing 3 types of IOLs at 3 postoperative time points, though the Fo-X was the only IOL to yield nearly emmetropic outcomes at all 3 time points.

Objective: Electroretinography (ERG) is used prior to cataract removal surgery to assess retinal function. We aimed to replicate and improve upon previous studies by performing a full ECVO protocol and by examining the retina post-surgery in all patients., Animals Studied: One hundred twenty-seven eyes from 67 dogs were included in the study., Procedures: A full ECVO protocol electroretinography, which includes extensive rod and cone analysis, was performed on all dogs presenting for cataract surgery., Results: Our main findings were that amplitudes, but not implicit times of rod responses decreased with advanced cataracts. Amplitudes of the single flash rod and rod flicker responses were significantly lower in eyes with mature cataracts, and the former also decreased in hypermature cataracts. Cone flicker amplitude responses were also significantly lower in eyes with mature and hypermature cataracts. However, mixed single flash rod-cone and cone responses, with the exception of the mixed rod-cone a-wave amplitude in eyes with hypermature cataracts, were unaffected by cataract stage. The b-wave amplitude of the scotopic, mixed rod-cone, and photopic cone responses were affected by age and decreased by an average of 2.9, 7.5, and 1.5 μV/year, retrospectively (p < 0.01)., Conclusions: Lower ERG amplitudes in canine cataract patients may result from aging or the presence of advanced cataracts and may not indicate the presence of retinal disease., (© 2022 American College of Veterinary Ophthalmologists.)

Purpose: Retrospectively evaluate prognostic indicators and outcome in dogs undergoing temporary tarsorrhaphy following traumatic proptosis., Methods: Medical records (2004-2017) were reviewed for signalment, cause and duration of proptosis, and clinical findings on admission. The operating faculty member, post-operative medications, and ophthalmic findings at last recheck were recorded. Owners of dogs with blinded eyes were surveyed regarding final outcome and satisfaction. Data were analyzed using Fisher's exact, Likelihood ratio, and Mann-Whitney tests., Results: At last recheck, 17.5 ± 7.3 (mean ± SD) days post-operatively, vision was present in 12/43 eyes (28%). Vision at last recheck was not correlated with breed, cause or duration of proptosis, or post-operative medications (P > .05), but was correlated with presence of direct and indirect pupillary light reflexes (PLRs) on admission (P = .001 and .02, respectively), and with assessment and surgery performed by veterinary ophthalmologists rather than surgery or emergency personnel (P = .015). Mean satisfaction scores (graded 0-10) of 22 owners contacted 59.6 ± 48.2 months after last recheck were 7.8 ± 2.6 (n = 6), 5.7 ± 4.9 (n = 3), and 8.8 ± 1.3 (n = 13) for dogs with phthisical eyes, eyes requiring long-term medications, and blind but otherwise normal eyes, respectively (P = .284)., Conclusions: Contrary to previous studies, breed, and cause and duration of proptosis, did not significantly affect outcome. Testing of direct and indirect PLR is a simple and significant prognostic indicator. Patients assessed and operated by a veterinary ophthalmologist have better prognosis., (© 2019 American College of Veterinary Ophthalmologists.)

Objective: To evaluate analgesic effects and complications associated with intraorbital insertion of an absorbable gelatin hemostatic sponge (AGHS) soaked with 1% ropivacaine solution following enucleation in dogs., Animals: 20 client-owned dogs undergoing enucleation., Procedures: Dogs were randomly assigned to receive an AGHS soaked with 1% ropivacaine solution (n = 10) or saline (0.9% NaCl) solution (control group; 10) inserted intraorbitally prior to skin closure following enucleation. Carprofen (2 mg/kg [0.9 mg/lb]) was administered SC once after orotracheal extubation and then PO twice a day for 5 days. During the postoperative recovery period, apparent pain level was scored at various points with a modified short-form Glasgow Composite Pain Scale (score range, 0 to 19), and methadone was administered for rescue analgesia if any score was ≥ 5. After dogs returned home, owners recorded their behavior and apparent pain level for the first 3 days following enucleation., Results: At extubation, the median (range) pain score was significantly higher in the control group (8 [2 to 14]) versus the ropivacaine group (3 [1 to 7]). A greater proportion of dogs in the control group received methadone (7/10 vs 1/10) and had crying or attention-seeking behavior on the first day following enucleation (7/10 vs 1/10). No complications were observed in either group., Conclusions and Clinical Relevance: Addition of intraorbital insertion of a ropivacaine-soaked AGHS to the analgesic protocol for dogs undergoing enucleation provided better analgesia than was achieved without this treatment as measured immediately and the first day after surgery, with no noted adverse effects.

Purpose: To conduct ophthalmic, behavioral, electrophysiological, and genetic testing on two related Gordon setters presented for day blindness and compare findings with those of nine related and unrelated Gordon setters., Methods: All dogs underwent comprehensive ophthalmic examination. Maze testing was conducted under different light intensities. Rod and cone function was assessed electroretinographically. DNA samples were screened for five canine retinal disease gene mutations., Results: Ophthalmic examination was unremarkable in all dogs. There was no notable difference between day blind dogs and the reference population in scotopic and mesopic maze tests. Day blind dogs performed worse in the photopic maze with slower course completion time and more obstacle collisions. Electroretinography revealed extinguished cone function in day blind dogs and depressed rod responses in all but two reference dogs. One reference population dog presented with day blindness 1 year after initial examination. Mutations that cause achromatopsia (in CNGB3) and cone-rod dystrophies (in ADAM9 and IQCB1) were not detected in any dog tested, although five reference dogs were carriers of the mutation in C2orf71 that causes rod-cone degeneration 4 (rcd4) in Gordon setters and in polski owczarek nizinny dogs., Conclusions: This report describes a novel retinopathy in related Gordon setters that has clinical signs and vision testing results consistent with achromatopsia but electroretinographic results suggestive of cone-rod dystrophy. The majority of Gordon setters in this study had low rod responses on electroretinography but it is unclear whether this was indicative of rod dysfunction or normal for the breed. Longer-term observation of affected individuals is warranted., (© 2015 American College of Veterinary Ophthalmologists.)

Purpose: This study describes the use of polymethylmethacrylate implants with interconnecting channels (PIIC) to fill the orbit following enucleation in 31 dogs and 11 cats., Method: Seven channels were drilled into the implant. A central channel, running from the PIIC pole to its flat surface, was used to pass sutures anchoring the PIIC to the orbital fascia, minimizing the likelihood of extrusion. Six more channels allowed ingrowth of fibrovascular tissue into the PIIC, which reduces the risk of extrusion. Patients were evaluated 3, 10, and 30 days postoperatively, with 15 of 42 patients followed for 6-20 months. Ultrasound examination was performed in seven patients 15-510 days postoperatively, and two implants were studied histopathologically., Results: Implants were well tolerated and prevented skin concavity, leading to good cosmetic results. Blood flow was imaged in vessels growing into the channels, and histopathologically a collagenous, fibrovascular capsule was seen surrounding the PIIC and invading its channels., Conclusions: PIICs are a safe and cosmetic solution to anophthalmic orbits, allowing ingrowth of blood vessels and fibrovascular tissue., (© 2015 American College of Veterinary Ophthalmologists.)

Objective: To perform a clinical, ophthalmological, and electroretinographic assessment of retinopathic lesions in German Shepherd dogs., Animals: The study was conducted on 14 German Shepherds diagnosed with retinopathy during the course of an ophthalmological checkup. The animals were systemically healthy police dogs used for patrolling and tracking duties and which were, at times, exposed to considerable physical strain and stress., Procedure: Periodic ophthalmological examinations using slit-lamp biomicroscopy, direct and indirect ophthalmoscopy, and photography, as well as maze testing, were performed on all dogs. Electroretinography (ERG) was performed on 10 affected German Shepherds and eight control dogs., Results: Ophthalmological examination revealed areas of tapetal hyper-reflectivity with pigmented centers, which were characteristic of inactive chorioretinitis. Most of the lesions were in proximity to blood vessels, and in a number of eyes, progression was observed during repeated examinations. Transition from active to inactive lesions, as well as onset in previously unaffected eyes, was also recorded. The ERG recordings showed impaired cone function, with significantly lower b-wave amplitudes and prolonged implicit times, in the mixed rod-cone, photopic, and flicker tests of affected dogs (P < 0.05)., Conclusions: Retinopathy observed in German Shepherd dogs is characterized by areas of tapetal hyper-reflectivity with pigmented centers. The underlying causes of retinopathy in German Shepherd dogs remain unknown, although husbandry conditions and proximity of the lesions to blood vessels may suggest an association with physical exertion or circulatory disorders, respectively., (© 2012 American College of Veterinary Ophthalmologists.)

This prospective study was conducted to evaluate the prevalence and severity of ocular lesions in dogs with anemia (packed cell volume < or =20%) and/or thrombocytopenia (platelet count<150,000/microL). Dogs were divided into four groups: (1) anemic (n=17); (2) thrombocytopenic (n=36); (3) anemic and thrombocytopenic (n=24); and (4) healthy controls (n=26). The prevalence of ophthalmic lesions in these four groups was 12%, 42%, 42% and 0%, respectively. Anemia was not associated with the presence of ocular lesions (P=0.41) or their severity. Thrombocytopenia was significantly associated with the presence of ocular lesions (P=0.0016) and with their severity (P=0.017). We conclude that thrombocytopenia, but not anemia, is associated with ocular lesions in dogs.

The aim of this study was to evaluate the efficacy of pimecrolimus oil-based eye drops in alleviating the clinical signs of keratoconjunctivitis sicca (KCS) in dogs and to compare the efficacy with that of cyclosporine A (CsA) ointment. An open-label, multicenter study enrolling 44 dogs previously untreated with CsA was conducted. Dogs were randomly assigned to a treatment group and medicated twice daily for 8 weeks. After that time the mean increase (+/-SEM) in the Schirmer tear test was 9.2+/-1.6 mm/min in the pimecrolimus group and 5.8+/-1.1 mm/min in the CsA group (P=0.085). The improvement in clinical signs of inflammation in eyes treated with pimecrolimus was significantly greater than in eyes treated with CsA (P=0.02). The results show that 1% pimecrolimus oily eye drops are as safe as and more effective than CsA ointment in controlling KCS in dogs.

Glaucoma and inherited retinal degeneration/dystrophy are leading causes of blindness in veterinary patients. Currently, there is no treatment for the loss of vision that characterizes both groups of diseases. However, this reality may soon change as recent advances in understanding of the disease processes allow researchers to develop new therapies aimed at preventing blindness and restoring vision to blind patients. Elucidating the molecular mechanisms of retinal ganglion cell death in glaucoma patients has led to the development of neuroprotective drugs which protect retinal cells and their function from the disastrous effects of elevated pressure. Identification of the genetic mutation responsible for inherited degenerations and dystrophies of the outer retina has enabled researchers using gene therapy to restore vision to blind dogs. Other patients may benefit from retinal transplantation, stem cell therapy, neuroprotective drugs, nutritional supplementation and even retinal prostheses. It is possible that soon it will be possible to restore sight to some blind patients.

Objective: To investigate the spectrum, prevalence and treatment response rate of ocular manifestations associated with natural canine monocytic ehrlichiosis (CME) due to Ehrlichia canis., Methods: The medical records of 90 dogs that were admitted for primary ocular problems and reacted positive for E. canis serum antibodies were reviewed. All the dogs were treated with oral doxycycline. In 79 dogs, a combination of systemic corticosteroids and/or topical anti-inflammatory, mydriatics/cycloplegics and antibacterial agents were applied., Results: The dogs ranged from 0.5 to 15 years in age; 55 were male and 35 female. A total of 19 breeds were represented. In the majority of dogs, ocular abnormalities were noticed in conjunction with other CME-induced clinical signs. In 30/90 dogs, ophthalmic signs were the sole presenting complaint. Unilateral (22/90, 24.5%) and bilateral (68/90, 75.5%) uveitis was the most common ophthalmic diagnosis and was classified as anterior, posterior or panuveitis in 58 (64.5%), 8 (8.9%) and 24 (26.6%) of the dogs, respectively. Bilateral uveitis was significantly more common than unilateral uveitis (P < 0.0001), and anterior significantly more common than posterior uveitis (P < 0.0001) or panuveitis (P < 0.0001). In addition, corneal ulceration (12/90, 13.3%), necrotic scleritis (10/90, 11.1%), low tear production (8/90, 8.9%) and orbital cellulitis (3/90, 3.3%) were seen. Of the 45 (50%) dogs with a satisfactory follow-up, 25 (55.5%), 11 (24.5%), and 9 (20%) showed complete, partial and poor response to treatment, respectively. The number of dogs exhibiting complete resolution of the ocular manifestations was significantly higher than those with partial (P < 0.0001) or poor (P < 0.0001) response., Conclusions: CME should be considered a major differential for a wide range of ocular manifestations exhibited by dogs residing in the endemic areas of the disease. Anterior bilateral uveitis appears to be the most prevalent ocular lesion and a favorable outcome to systemic and topical treatment may be expected in the majority of the affected dogs.

A 3-year-old, intact male, mixed breed dog was presented with a complaint of acute blindness. Ten days previously, the area where the dog was walking came under a rocket attack, and a rocket landed and exploded 300 meters away from the dog. Physical examination was unremarkable. Ophthalmoscopic examination revealed posterior segment fibrin clots and extensive vitreal hemorrhage in the right eye. A total retinal detachment (360 degrees retinal dialysis) with no evidence of hemorrhage was noted in the left eye. There was no sign of any penetrating ocular trauma, and it was assumed that the posterior segment findings were primary injuries caused by the blast wave itself. Following anti-inflammatory treatment, partial vision was restored in the right eye. Surgical re-attachment of the retina was discussed and declined by the owner. This report describes, for the first time, vitreal hemorrhage and retinal detachment as the sole injuries caused by an explosive blast wave.

Purpose: To examine variables that affect publication of ACVO meeting abstracts in peer‐reviewed journals and compare results to ECVO publication rate (PR). Methods: Published papers were identified via online searches for abstracts from 2008 to 2012 ACVO/ECVO meetings. Variables analyzed (via Pearson's chi‐Squared test) included the following: oral presentation/poster, type of abstract (clinical/basic science/case report), species, ocular tissue, nationality, funding, first/last/any author a diplomate, resident as first author, and author affiliation (private practice/university). Results: One hundred and eighty‐six of 577 ACVO abstracts were published within 608 ± 479 days, with 103 published in Veterinary Ophthalmology. Significant factors included the following: nationality of first/last authors (P =.005); English as first language (P <.001); presentation type (P <.001, oral 40% PR, poster 22% PR); type of study (P =.037, clinical study 35% PR, basic science 30% PR, case report 16% PR); resident as first author (P <.001); diplomate as any author except first/last (P <.001); first author affiliation (P =.001, university 37% PR, practice 21% PR); last author affiliation (P =.003, university 36% PR, practice 22% PR); and species (P <.001, horses 53% PR, multiple species 50% PR, cats 35% PR, food animals 31% PR, exotics/wildlife 31% PR, dogs 27% PR, laboratory animals/in vitro 24%). Nonsignificant factors were as follows: diplomate as first/last author, funding, and ocular tissue. Presentation type, resident as first author, university affiliation of first author, and species had the greatest effect on publication probability. For the same period, ECVO PR was 87 of 299, which was not significantly different from ACVO PR (P =.342). Conclusion: At 32%, ACVO PR for the study years is similar to ECVO PR of 29%. [ABSTRACT FROM AUTHOR]

Purpose Prostaglandin analogs contribute to blood-aqueous barrier breakdown and may exacerbate uveitis. As these analogs induce de novo synthesis of endogenous prostaglandins, their therapeutic, hypotensive effect could potentially be inhibited by anti-inflammatory treatment. We therefore evaluated whether topical 1% prednisolone acetate alters the effects of 0.005% latanoprost on pupil diameter ( PD) and intraocular pressure ( IOP). Animals studied Ten healthy Labrador retriever dogs from the Israel Guide Dog Center for the Blind. Methods Pupil diameter and IOP were measured hourly, 8 AM-4 PM, with the right and left eyes serving as control ( CE) and treated ( TE) eyes, respectively. Measurements were conducted during four sessions: (1) without treatment ( n = 10), (2) following latanoprost treatment ( n = 10) at 8 AM, (3) following prednisolone treatment ( n = 7) at 8 AM, and (4) bilateral latanoprost treatment at 8 AM, prednisolone treatment in TE at 11 AM ( n = 8). The different number of dogs in sessions 3 and 4 is because some dogs were matched with their new owners earlier than expected. Results Pupil diameters were not affected by the addition of prednisolone and, at 4 PM, were 3.82 ± 0.47 and 3.97 ± 0.36 mm in TE and CE, respectively ( P = 0.175, Wilcoxon). IOPs were not affected by the addition of prednisolone and, at 4 PM, were 9.0 ± 0.8 and 9.3 ± 0.8 mm Hg in TE and CE, respectively ( P = 0.339, Wilcoxon). Conclusion Prednisolone did not alter latanoprost's miotic and hypotensive effects in normal dogs during this study period. [ABSTRACT FROM AUTHOR]

Purpose Prostaglandin analogs induce miosis and lower intraocular pressure ( IOP). As pupils of latanoprost-treated eyes may have to be dilated for ophthalmoscopy or intraocular surgery, we studied whether 0.5% tropicamide or 1% atropine alter the effects of 0.005% latanoprost on pupil diameter ( PD) and IOP in healthy dogs. Methods IOP and PD were measured hourly, 8 AM-4 PM, with the right and left eyes serving as control ( CE) and treated ( TE) eyes, respectively. Measurements were conducted in ten Labrador retrievers with one-week washout: (i) baseline values, (ii) latanoprost at 8 AM, (iii) tropicamide at 8 AM, (iv) latanoprost at 8 AM and tropicamide at 11 AM, and (v) latanoprost at 8 AM and atropine at 11 AM ( n = 4). Results At 4 PM, TE PD was 5.88 ± 0.59, 3.62 ± 0.66, 6.33 ± 1.00, 5.42 ± 0.57, and 8.12 ± 1.24 mm in sessions 1-5, respectively. TE PD was significantly different between treatment sessions 2, 4, and 5 ( P = 0.018, Friedman), being most mydriatic in session 5. At 4 PM, TE IOP was 11.27 ± 2.07, 7.10 ± 1.07, 11.1 ± 2.21, 7.70 ± 1.85, and 8.87 ± 1.42 mm Hg in sessions 1-5, respectively, with no differences between treatment sessions 2, 4, and 5 ( P = 0.105, Friedman). Conclusions Tropicamide and atropine counteracted latanoprost's miotic effect, with atropine causing significantly larger mydriasis, sufficient for indirect ophthalmoscopy. Neither drug counteracted the hypotensive effect of latanoprost during this study period. Further studies are necessary to evaluate the potential risks in glaucomatous dogs. [ABSTRACT FROM AUTHOR]

Objective To compare the Welch Allyn SureSight™ wavefront autorefractor with retinoscopy in normal dogs. Animals studied Fifty privately owned dogs (100 eyes) of 20 breeds, free of ocular disease. Mean ± SD age: 5.7 ± 3.25 years (range: 6 months-13 years). Procedures The refractive error was determined in each eye by two experienced retinoscopists using streak retinoscopy as well as by an autorefractor operated by two different examiners. Measurements were performed before and approximately 30-45 min after cycloplegia was induced by cyclopentolate 0.5% and tropicamide 0.5% ophthalmic solutions. Results Mean ± SD noncyclopleged retinoscopy net sphere was −0.55 ± 1.14 (range: −3.75 to 3.5) diopters (D). Mean cyclopleged retinoscopy net sphere was −0.52 ± 1.18 (range: −4.25 to 2) D. Mean ± SD noncyclopleged autorefractor spherical equivalent (SE) was −0.42 ± 1.13 D (range: −3.36 to 2.73) D. Mean cyclopleged autorefractor SE was 0.10 ± 1.47 (range: −5.62 to 3.19) D. Noncyclopleged autorefraction results were not significantly different from streak retinoscopy (whether noncyclopleged or cyclopleged, P = 0.80 and P = 0.26, respectively). Cyclopleged autorefraction results were significantly different from noncyclopleged or cyclopleged streak retinoscopy ( P < 0.0001 in both states). There was no significant difference between noncyclopleged and cyclopleged streak retinoscopy ( P = 0.97). Conclusions Noncyclopleged autorefraction shows good agreement with streak retinoscopy in dogs and may be a useful clinical technique. Cycloplegia does not significantly affect streak retinoscopy results in dogs. [ABSTRACT FROM AUTHOR]

Objective--To measure the effect of induced myopia on field trial performance in dogs. Animals--7 Labrador Retrievers and 1 Chesapeake Bay Retriever trained in field trial competition. Procedures--Dogs were commanded to retrieve targets at 137.2 m (150 yards). Each dog participated in 3 trials while their eyes were fitted with 0- (piano), +1.50-, or +3.00-diopter (D) contact lenses, applied in random order. Retrieval times were measured objectively, and dog performances were evaluated subjectively by masked judges. Results--Retrieval times were significantly faster with piano lenses than with +1.50- or +3.00-D lenses, but there were no significant differences in times between +1.50- and +3.00-D lenses. Masked judges assigned the best performance scores to dogs with piano lenses and the lowest scores to dogs fitted with +3.00-D lenses. Conclusions and Clinical Relevance--Even mild myopic defocusing had a significant negative impact on both the subjective and objective assessments of dogs' performances. Dogs with demanding visual tasks or signs of visual deterioration should be evaluated retinoscopically to determine the refractive state because they may have ametropia. [ABSTRACT FROM AUTHOR]

Objective--To quantitatively and qualitatively compare electroretinography (ERG) recordings in awake, sedated, and anesthetized dogs. Animals--Six 6-month-old Beagles. Procedures--A brief ERG protocol for dogs was used. Following 1-minute and subsequent 5-minute dark adaptation, mixed rod-cone responses were recorded bilaterally with a handheld multispecies ERG device with dogs in each of 3 states of consciousness: awake, sedated (dexmedetomidine and butorphanol), and anesthetized (atropine and hydromorphone, followed by propofol and midazolam and anesthetic maintenance with isoflurane). Low- and high-frequency noise levels were quantified via Fourier analysis, and the effect of consciousness state on signal amplitude, implicit time, and noise was analyzed via repeated-measures ANOVA. In addition, 13 veterinary ophthalmologists who were unaware of the dogs' consciousness states subjectively graded the ERG recording quality, and scores for each tracing were compared. Results--ERG amplitudes were highest in awake dogs and lowest in anesthetized dogs. Implicit times were shortest in awake dogs and longest in anesthetized dogs. Differences in b-wave amplitudes and a-wave implicit times were significant. Neither low- nor high-frequency noise levels differed significantly among consciousness states. Furthermore, no significant differences were identified among observers' scores assigned to ERG tracings. Conclusions and Clinical Relevance--Anesthesia and sedation resulted in significant attenuation and delay of ERG responses in dogs. Chemical restraint of dogs had no consistently significant effect on low- or high-frequency noise levels or on observer perception of signal quality. [ABSTRACT FROM AUTHOR]