1. The effect of prophylactic tranexamic acid on the incidence of postoperative hemorrhage in greyhounds.
- Author
-
Gilman OP, Borgeat K, and Wilson HE
- Subjects
- Dogs, Animals, Retrospective Studies, Incidence, Female, Male, Tranexamic Acid administration & dosage, Tranexamic Acid therapeutic use, Antifibrinolytic Agents administration & dosage, Antifibrinolytic Agents therapeutic use, Postoperative Hemorrhage prevention & control, Postoperative Hemorrhage epidemiology, Postoperative Hemorrhage veterinary, Dog Diseases prevention & control, Dog Diseases epidemiology
- Abstract
To investigate whether the incidence of postoperative hemorrhage in greyhounds was reduced when a standardized protocol for prophylactic tranexamic acid (TXA) administration to greyhounds undergoing surgery was followed, a retrospective clinical study at a private referral and first opinion hospital group was performed. Patient records of client-owned greyhounds undergoing elective surgery or dental procedures involving extractions were examined retrospectively, and 58 incidents of surgery considered eligible were documented, along with any subsequent reports of hemorrhage and whether the TXA protocol was followed. The use of TXA was not associated with a reduction in the incidence of postoperative hemorrhage in this population of greyhounds. In the group that did not receive TXA, post-operative hemorrhage was reported in 7/37 (18.9 %) cases and in the prophylactic TXA group, post-operative hemorrhage was reported in 11/21 (52.4 %) cases, a significantly higher number than in the group that did not receive TXA. Interestingly, in our population, prophylactic administration of TXA was not associated with a reduction in post-operative hemorrhage, but with a higher incidence of hemorrhage. We belief that descrepencies in our dataset may explain these findings, and a prospective randomized-controlled trial should be performed to further investigate the efficacy of TXA as an antifibrinolytic agent in greyhounds., Competing Interests: Conflict of interest statement None of the authors has any other financial or personal relationships that could inappropriately influence or bias the content of the paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF