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Petrographic, structural and geochemical analysis combined with SEM and XRD were performed on the Boumaadine Fe–Mn–Pb–Cu (±Au) mineralization of Jbel Skindis in the eastern High Atlas, (Morocco). The results indicate a polyphasic process of mineralization, which produced orebodies with distinct features and different chemical conditions formation. The earliest mineralization formed replacement and disseminated Fe–Mn–Pb orebodies under oxidizing conditions, with a mineral assemblage composed of coronadite, plumboferrite, cesarolite, specularite and calcite, in association with a large-scale hydrothermal alteration consisting essentially of Fe–Mn minerals, i.e., ferroan dolomite, hematite, jacobsite and limonite. The second event was formed under reducing conditions that generate some veins filled mainly by sulfides (galena, with minor pyrite and chalcopyrite), in addition of calcite and dolomite. The mineralization is hosted in Lower Liassic dolostones and is linked to the structural evolution of the study area. Fractures related to the displacement of the Boumaadine fault seem to control the disposition and the localization of the alteration and the mineralization: (i) the Fe–Mn–Pb oxides are related to a NE-SW conjugate fault system generated during the first phase of deformation, with a horizontal principal stress striking NNW-SSE, and (ii) the sulfide mineralization occurs mainly as filling conjugate fractures of two preferentially directions striking N80–90 and N150-165 with a slight dip (15–40°) to the NE. These latter were caused by a dextral movement along the Boumaadine fault, generated during the late phase of deformation with a NW-SE bearing horizontal principal stress. The deep-seated Boumaadine fault has acted as pathways for the rising fluids, and supports the origin of lead and other metals from the Paleozoic basement. The Triassic evaporitic sequence along the Boumaadine fault has also contributed to the chemical composition of the fluid, and represents the potential source of both the salinity and sulfur. The oxide-sulfide mineralogical assemblage and its associated alteration emphasize a polyphasic hydrothermal activity with distinct physicochemical conditions; an iron-manganese rich, and highly oxidizing brine is considered to be responsible for the Fe–Mn alteration and for the deposit of the oxide assemblage. Furthermore, a mixing of the oxidizing fluid with a meteoric reducing fluid could have resulted in the sulfide-rich ore. • The deposits indicate a polyphasic process of mineralization. • The earliest mineralization formed replacement and disseminated Fe-Mn-Pb orebodies under oxidizing conditions. • The second event was formed under reducing conditions that generate veins filled mainly by sulfides. • The mineralization is structurally controlled, in relation to the major alpine compressional events. [ABSTRACT FROM AUTHOR]