9 results on '"Fecteau, Shirley"'
Search Results
2. Impulsivity and Substance-Use Disorders
- Author
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Labbe, Sara, Fecteau, Shirley, Brunoni, André, editor, Nitsche, Michael, editor, and Loo, Colleen, editor
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- 2016
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3. Does non-invasive brain stimulation applied over the dorsolateral prefrontal cortex non-specifically influence mood and emotional processing in healthy individuals?
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Mondino, Marine, Thiffault, François, Fecteau, Shirley, Clark, Vincent, and Plewnia, Christian
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TRANSCRANIAL magnetic stimulation ,BRAIN stimulation ,MAGNETOTHERAPY ,TRANSCRANIAL direct current stimulation ,EMOTIONS ,PREFRONTAL cortex - Abstract
The dorsolateral prefrontal cortex (DLPFC) is often targeted with non-invasive brain stimulation (NIBS) to modulate in vivo human behaviors. This brain region plays a key role in mood, emotional processing, and attentional processing of emotional information. In this article, we ask the question: when we target the DLPFC with NIBS, do we modulate these processes altogether, non-specifically, or can we modulate them selectively? We thus review articles investigating the effects of NIBS applied over the DLPFC on mood, emotional processing, and attentional processing of emotional stimuli in healthy subjects. We discuss that NIBS over the DLPFC can modulate emotional processing and attentional processing of emotional stimuli, without specifically influencing mood. Indeed, there seems to be a lack of evidence that NIBS over the DLPFC influences mood in healthy individuals. Finally, there appears to be a hemispheric lateralization: when applied over the left DLPFC, NIBS improved processing of positive stimuli and reduced selective attention for stimuli expressing anger, whereas when applied over the right DLPFC, it increased selective attention for stimuli expressing anger. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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4. Neuromodulation of Decision-Making in the Addictive Brain.
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Fecteau, Shirley, Fregni, Felipe, Boggio, Paulo S., Camprodon, Joan A., and Pascual-Leone, Alvaro
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BRAIN stimulation , *DECISION making , *PREFRONTAL cortex , *TRANSCRANIAL magnetic stimulation , *DRUG addiction , *COMPULSIVE behavior - Abstract
Noninvasive brain stimulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation and transcranial direct current stimulation can modify decision-making behaviors in healthy subjects. The same type of noninvasive brain stimulation can suppress drug craving in substance user patients, who often display impaired decision-making behaviors. We discuss the implications of these studies for the cognitive neurosciences and their translational applications to the treatment of addictions. We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders. [ABSTRACT FROM AUTHOR]
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- 2010
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5. Diminishing Risk-Taking Behavior by Modulating Activity in the Prefrontal Cortex: A Direct Current Stimulation Study.
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Fecteau, Shirley, Knoch, Daria, Fregni, Felipe, Sultani, Natasha, Boggio, Paulo, and Pascual-Leone, Alvaro
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RISK-taking behavior , *NEURAL stimulation , *PREFRONTAL cortex , *DECISION making , *BRAIN - Abstract
Studies have shown increased risk taking in healthy individuals after low-frequency repetitive transcranial magnetic stimulation, known to transiently suppress cortical excitability, over the right dorsolateral prefrontal cortex (DLPFC). It appears, therefore, plausible that differential modulation of DLPFC activity, increasing the right while decreasing the left, might lead to decreased risk taking, which could hold clinical relevance as excessively risky decision making is observed in clinical populations leading to deleterious consequences. The goal of the present study was to investigate whether risk-taking behaviors could be decreased using concurrent anodal transcranial direct current stimulation (tDCS) of the right DLPFC, which allows upregulation of brain activity, with cathodal tDCS of the left DLPCF, which downregulates activity. Thirty-six healthy volunteers performed the risk task while they received either anodal over the right with cathodal over the left DLPFC, anodal over the left with cathodal over the right DLPFC, or sham stimulation. We hypothesized that right anodal/left cathodal would decrease risk-taking behavior compared with left anodal/right cathodal or sham stimulation. As predicted, during right anodal/left cathodal stimulation over the DLPFC, participants chose more often the safe prospect compared with the other groups. Moreover, these participants appeared to be insensitive to the reward associated with the prospects. These findings support the notion that the interhemispheric balance of activity across the DLPFCs is critical in decision-making behaviors. Most importantly, the observed suppression of risky behaviors suggests that populations with boundless risk-taking behaviors leading to negative real-life consequences, such as individuals with addiction, might benefit from such neuromodulation-based approaches. [ABSTRACT FROM AUTHOR]
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- 2007
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6. Modulation of Untruthful Responses with Non-Invasive Brain Stimulation
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Fecteau, Shirley, Boggio, Paulo, Fregni, Felipe, and Pascual-Leone, Alvaro
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deception ,dorsolateral prefrontal cortex ,brain stimulation ,verbal communication - Abstract
Deceptive abilities have long been studied in relation to personality traits. More recently, studies explored the neural substrates associated with deceptive skills suggesting a critical role of the prefrontal cortex. Here we investigated whether non-invasive brain stimulation over the dorsolateral prefrontal cortex (DLPFC) could modulate generation of untruthful responses about subject’s personal life across contexts (i.e., deceiving on guilt-free questions on daily activities; generating previously memorized lies about past experience; and producing spontaneous lies about past experience), as well as across modality responses (verbal and motor responses). Results reveal that real, but not sham, transcranial direct current stimulation (tDCS) over the DLPFC can reduce response latency for untruthful over truthful answers across contexts and modality responses. Also, contexts of lies seem to incur a different hemispheric laterality. These findings add up to previous studies demonstrating that it is possible to modulate some processes involved in generation of untruthful answers by applying non-invasive brain stimulation over the DLPFC and extend these findings by showing a differential hemispheric contribution of DLPFCs according to contexts.
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- 2013
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7. Online Effects of Transcranial Direct Current Stimulation in Real Time on Human Prefrontal and Striatal Metabolites.
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Hone-Blanchet, Antoine, Edden, Richard A., and Fecteau, Shirley
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TRANSCRANIAL direct current stimulation , *PREFRONTAL cortex , *BRAIN stimulation , *MEDICAL protocols , *AMINOBUTYRIC acid - Abstract
Background Studies have reported that transcranial direct current stimulation (tDCS) can modulate human behaviors, symptoms, and neural activity; however, the neural effects during stimulation are unknown. Most studies compared the effects of tDCS before and after stimulation. The objective of our study was to measure the neurobiological effect of a single tDCS dose during stimulation. Methods We conducted an online and offline protocol combining tDCS and magnetic resonance spectroscopy (MRS) in 17 healthy participants. We applied anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC) and cathodal tDCS over the right DLPFC for 30 minutes, one of the most common montages used with tDCS. We collected MRS measurements in the left DLPFC and left striatum during tDCS and an additional MRS measurement in the left DLPFC immediately after the end of stimulation. Results During stimulation, active tDCS, as compared with sham tDCS, elevated prefrontal N -acetylaspartate and striatal glutamate + glutamine but did not induce significant differences in prefrontal or striatal gamma-aminobutyric acid level. Immediately after stimulation, active tDCS, as compared with sham tDCS, did not significantly induce differences in glutamate + glutamine, N -acetylaspartate, or gamma-aminobutyric acid levels in the left DLPFC. Conclusions These observations indicate that tDCS over the DLPFC has fast excitatory effects, acting on prefrontal and striatal transmissions, and these effects are short lived. One may postulate that repeated sessions of tDCS might induce similar longer lasting effects of elevated prefrontal N -acetylaspartate and striatal glutamate + glutamine levels, which may contribute to its behavioral and clinical effects. [ABSTRACT FROM AUTHOR]
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- 2016
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8. Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: A double-blind, sham-controlled study
- Author
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Boggio, Paulo S., Sultani, Natasha, Fecteau, Shirley, Merabet, Lotfi, Mecca, Tatiana, Pascual-Leone, Alvaro, Basaglia, Aline, and Fregni, Felipe
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ALCOHOL drinking , *BRAIN function localization , *NEUROPHYSIOLOGY , *PHRENOLOGY - Abstract
Abstract: Background: Functional neuroimaging studies have shown that specific brain areas are associated with alcohol craving including the dorsolateral prefrontal cortex (DLPFC). We tested whether modulation of DLPFC using transcranial direct current stimulation (tDCS) could alter alcohol craving in patients with alcohol dependence while being exposed to alcohol cues. Methods: We performed a randomized sham-controlled study in which 13 subjects received sham and active bilateral tDCS delivered to DLPFC (anodal left/cathodal right and anodal right/cathodal left). For sham stimulation, the electrodes were placed at the same positions as in active stimulation; however, the stimulator was turned off after 30s of stimulation. Subjects were presented videos depicting alcohol consumption to increase alcohol craving. Results: Our results showed that both anodal left/cathodal right and anodal right/cathodal left significantly decreased alcohol craving compared to sham stimulation (p <0.0001). In addition, we found that following treatment, craving could not be further increased by alcohol cues. Conclusions: Our findings showed that tDCS treatment to DLPFC can reduce alcohol craving. These findings extend the results of previous studies using noninvasive brain stimulation to reduce craving in humans. Given the relatively rapid suppressive effect of tDCS and the highly fluctuating nature of alcohol craving, this technique may prove to be a valuable treatment strategy within the clinical setting. [Copyright &y& Elsevier]
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- 2008
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9. Cognitive Functions in Substance-Related and Addictive Disorders
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Sara Garofalo, Shirley Fecteau, Amy E. Bouchard, Claude Rouillard, Bouchard, Amy E., Garofalo, Sara, Rouillard, Claude, and Fecteau, Shirley
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business.industry ,Addiction ,media_common.quotation_subject ,Cognition ,Craving ,Executive functions ,Cognitive bias ,Dorsolateral prefrontal cortex ,Mood ,medicine.anatomical_structure ,medicine ,Cognitive skill ,medicine.symptom ,business ,Substance-related and addictive disorders Executive functions Cognitive bias Dorsolateral prefrontal cortex ,Neuroscience ,media_common - Abstract
Despite the availability of treatments such as medications and cognitive behavioural therapy, relapse remains high in substance-related and addictive disorders. Cognitive functions, including cognitive biases and executive functions, are significant predictors of relapse. Alleviating cognitive deficits is therefore promising to suppress craving and decrease relapse. Transcranial current stimulation holds potential to improve cognitive functioning in these patients. This chapter provides an overview of the use of transcranial current stimulation to modulate cognitive functions in substance-related and addictive disorders. We show that transcranial current stimulation can decrease cognitive biases and improve executive functions across various substance-related and addictive disorders, especially regarding decision-making and when targeting the dorsolateral prefrontal cortex bilaterally. We also discuss the relationship between cognitive functions and several processes, such as craving, mood, and stress, which should be taken into account when developing future transcranial current stimulation protocols. Finally, we provide suggestions as to how future studies could be improved to better treat patients with these debilitating disorders.
- Published
- 2021
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