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Ten novel spectrophotometric approaches were developed for the initial examination of the Hydroxychloroquine and Paracetamol medications. These procedures are straightforward, specific, easy to use, and provide exact and accurate results. The determination was conducted through the utilization of several approaches, including zero order (dual wavelength, zero crossing, advanced absorption subtraction and spectrum subtraction), derivative (first derivative of zero crossing), ratio (ratio difference, ratio derivative) and mathematical (bivariate, simultaneous equation, and Q-absorbance) techniques. After undergoing validation in accordance with ICH criteria, it was established that each of these methods achieved acceptable levels of precision, repeatability, robustness, and accuracy. The advantages and disadvantages of each method are demonstrated, and the proposed and reported methodologies were statistically compared. [ABSTRACT FROM AUTHOR]

Two novel potentiometric sensors were developed for the quantification of olopatadine hydrochloride and oxeladine citrate in pure forms, pharmaceutical preparations and human plasma. The both sensors were fabricated on incorporating the olopatadine and oxeladine tetraphenylborate ion-pairs as electroactive materials in plasticized poly (vinyl chloride) matrix membranes with o- nitrophenyl octyl ether. They displayed Nernstian and near Nernstian responses over the concentration ranges of 1.0 × 10−5–1.0 × 10−2 mol L−1 oxeladine and olopatadine with cationic slopes of 60 and 50 mV decade−1, respectively. Detection limits were reported to be 4.4 × 10−6 and 5.0 × 10−6 mol L−1 while the response times were 3.0 and 18 s for oxeladine and olopatadine, respectively. The useful ranges of pH were 2.5–8.5 and 3.0–4.5 for oxeladine and olopatadine, respectively. The life extents were long (3 months) for both sensors. The sensors were successfully used for the assay of oxeladine and olopatadine in pharmaceutical dosage forms with a recovery of 100.0% for both drugs. Also the oxeladine sensor was used for the estimation of the drug in human plasma with an average recovery of 99.49%. • This work involves a development of novel sensors for olopatadine and oxeladine drugs based on using drug-tetraphenyl borate ion-pairs as electroactive materials. • The sensors are used for the determination of the drugs in pure forms, pharmaceutical preparations, and human plasma. • There is no potentiometric sensor reported for the estimation of olopatadine, so far. • These methods are simple, direct, accurate, sensitive and cost affordable for the estimation of the drugs, and also validated for use either in drug quality-control or pharmacokinetic studies according to the quality-assurance standards. [ABSTRACT FROM AUTHOR]

Six simple, specific, accurate and precise spectrophotometric methods were developed for the first time analysis of some co-administered drugs with paracetamol in their mixture form without prior separation. Paracetamol & orphenadrine citrate were determined by using dual wavelength, bivariate, ratio difference, ratio derivative and mean centering of ratio spectra methods. Paracetamol & caffeine were determined by using ratio difference, ratio derivative and mean centering of ratio spectra methods. Paracetamol & diclofenac sodium were determined by using advanced absorption subtraction, ratio difference, ratio derivative and mean centering of ratio spectra methods. All of these methods were validated according to ICH guidelines where accuracy, precision, repeatability and robustness were found to be within the accepted limits. Advantages and limitations of each method are demonstrated and statistical comparison between the proposed methods was performed. Six spectrophotometric methods can be used to resolve the overlapping of some co-administered drugs with paracetamol such as paracetamol & orphenadrine citrate, paracetamol & caffeine and paracetamol & diclofenac sodium. Overlapping spectra of some co-administered drugs with paracetamol. Unlabelled Image • Analysis of Paracetamol & Orphenadrine citrate in a combined dosage form by using Dual wavelength, Bivariate, Ratio difference, Ratio derivative and Mean centering of ratio spectra methods. • Analysis of Paracetamol & Caffeine in a combined dosage form by using Ratio difference, Ratio derivative and Mean centering of ratio spectra methods. • Analysis of Paracetamol & Diclofenac sodium in a combined dosage form by using Advanced absorption subtraction, Ratio difference, Ratio derivative and Mean centering of ratio spectra methods. but the editor asked me to reduce the number of words so the highlights were shrunk to one sentence. [ABSTRACT FROM AUTHOR]