1. [Plasma protein and cerebral soluble protein disc electrophoresis in Down's syndrome].
- Author
-
Baryshevskaia GD, Mikhneva LM, and Usova IuI
- Subjects
- Adolescent, Child, Child, Preschool, Densitometry, Down Syndrome blood, Electrophoresis, Disc, Frontal Lobe analysis, Humans, Reference Values, Solubility, Blood Proteins analysis, Brain Chemistry, Down Syndrome metabolism, Nerve Tissue Proteins analysis
- Abstract
Blood plasma proteins and soluble proteins from brain lobus frontalis of patients with mongolism were studied using polyacrylamide gel disc electrophoresis. A decrease in content of albumins, proteins of Gc system, transferrine, fast posttransferrines and an increase in amount of immunoglobulin proteins as well as of alpha 2-macroglobulin were observed in the preparations of blood plasma proteins. These alterations were apparently determined by impairments in functions of protein-synthesizing systems. Content of four different protein fractions was altered as shown by brain proteinogramms.
- Published
- 1980