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What is known and objective: Invasive fungal infections often occur in patients with comorbidities that complicate oral administration. Serum concentrations of isavuconazole were characterized after enteral tube administration. Case description: Thirteen of 14 isavuconazole concentrations were >1 mg/dl (median 1.6 mg/dl) among those receiving enteral tube administration, which was comparable to intravenous (median 1.9 mg/dl). Higher concentrations were observed during oral administration (median 3 mg/dl). What is new and conclusion: Administration of isavuconazole via tube resulted in concentrations comparable to FDA‐approved routes of administration. This route may be feasible and appropriate for select patients. [ABSTRACT FROM AUTHOR]