1. Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs.
- Author
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Fornell, Jordina, Soriano, Jorge, Guerrero, Miguel, de Dios Sirvent, Juan, Ferran-Marqués, Marta, Ibáñez, Elena, Barrios, Leonardo, Baró, Maria Dolors, Suriñach, Santiago, Nogués, Carme, Sort, Jordi, and Pellicer, Eva
- Subjects
BIODEGRADABLE materials ,MACROPOROUS polymers ,FERROMAGNETISM ,DRUG delivery systems ,ARTIFICIAL membranes - Abstract
Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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