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The solid lipid nanoparticle of an anti-fungal drug is prepared in the present study and the drug luliconazole loaded nanoparticles have been poured into the matrix of aloe vera gel to improve drug penetration through the skin. Luliconazole solid lipid nanoparticles (SLN-LCZ) are formulated via the process of solvent emulsification to ensure improved trapping efficiency and continuous drug delivery. Aloe vera gel demonstrated with medicinal capabilities and excellent care as per WHO "Portal of health products & essential medicine". Compared to other standard anti-fungal creams, the in vitro evaluation of SLN-LCZ gel showed brilliant spreadability, adhesiveness & easy application, as well as a better in vitro drug release profile. Gel formulation stability was also found to be stable at low temperatures of up to 2°C as well as high temperatures of up to 40°C. Finally, the SLN-LCZ-containing aloe vera gel formulation for topical drug delivery proves to be a promising nano carrier for the delivery of drugs targeting infectious skin diseases. The formulations have been shown to be effective, consistent with increased drug penetration to the skin achieved. [ABSTRACT FROM AUTHOR]

Microsponge drug delivery system (MDS) was developed to deliver the pharmaceutical ingredients efficiently at the site of administration at a limited dose. MDS is based on pore size of sponges. The action of microsponges lasts up to 12 hours. MDS is also dependent on the physicochemical properties of the drug. These are used in bone tissue engineering, for reducing skin irritation and have a self-sterilisation property. This review provides an overview regarding the characteristics, methods of preparation, properties, evaluation, applications and limitations of MDS. [ABSTRACT FROM AUTHOR]

Cancer has become the leading cause of death among different populations of the world. The treatment is limited to chemotherapy, radiation, and surgery. Selective targeting to the tumor cells is possible by nanoparticles-based drug delivery system. It maximizes the drug concentration at the desired target and protects the surrounding healthy tissues at the same time. To improve the targeting potential of the anticancer drugs, nanoparticles were optimized for the size and surface characteristics to enhance their circulation time and targeting efficiency. Passive targeting involves surface modification with polyethylene glycol to avoid its elimination by natural body defense mechanism. Active targeting involves chemical interaction with certain antigen, receptors, and genes which are over expressed during progression of disease. In addition, the article highlights recent developments in 'smart'-stimulus-responsive-drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug. Enhanced targeting potential, imaging, and controlled release of drugs or therapeutic molecules could be possible through multi-functional nanocarrier. Such multi-faceted, versatile nanocarriers and drug delivery systems promise a substantial increase in the efficacy of diagnostic and therapeutic applications in pharmaceutical sciences. [ABSTRACT FROM AUTHOR]