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Conventional drug delivery systems are associated with various shortcomings, including low bioavailability and limited control over release. Biodegradable polymeric microparticles have emerged as versatile carriers in drug delivery systems addressing all these challenges. This comprehensive review explores the dynamic landscape of microparticles, considering the role of hydrophilic and hydrophobic materials. Within the continuously evolving domain of microparticle preparation methods, this review offers valuable insights into the latest advancements and addresses the factors influencing microencapsulation, which is pivotal for harnessing the full potential of microparticles. Exploration of the latest research in this dynamic field unlocks the possibilities of optimizing microencapsulation techniques to produce microparticles of desired characteristics and properties for different applications, which can help contribute to the ongoing evolution in the field of pharmaceutical science., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Present effort intends to improve the performance of gelatin based casted-films for controlled delivery of hydrophobic drugs. To achieve this goal, Piperine (a model drug) was loaded into gelatin (type A) casted-films by solvent evaporation method. Glutaraldehyde was used as a cross-linker for the gelatin films to modulate the drug release behavior and to prolong the rate of degradation of the film.In-vitrodegradation study under physiological conditions and thermal analysis through differential scanning calorimetry were performed to confirm stability of the gelatin casted-film matrix. Aim was to control the drug release from films by varying the cross-linking degree and the gelatin concentration. Optical microscope analysis was performed to study the surface topography of the sample. In order to understand the drug–polymer interaction in the film, attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) analysis was done. Thein-vitrorelease study gave an overall idea of the role of cross-linkers, gelatin concentration, and effect of pH on the release profiles of Piperine. Results show that one can effectively use gelatin casted-film based drug delivery systems for a wide range of release requirements, i.e., from fast release to delayed release. [ABSTRACT FROM PUBLISHER]

The article discusses a study which investigated an intraelectrode phenomenon, where the electrode allows ionic diffusion and migration from adjacent electrical double layer into itself. The study examined the dynamics of the build up of charge and concentration profiles inside such polymeric electrode. It identified the effects of low diffusivity and the finite rates of neutralization together. The applications of P-based electrodes to drug delivery are explored as well.

[Display omitted] The Oral route of administration forms the heartwood of the ever-growing tree of drug delivery technology. It is one of the most preferred dosage forms among patients and controlled release community. Despite the high patient compliance, the deliveries of anti-cancerous drugs, vaccines, proteins, etc. via the oral route are limited and have recorded a very low bioavailability. The oral administration must overcome the physiological barriers (low solubility, permeation and early degradation) to achieve efficient and sustained delivery. This review aims at highlighting the conventional and modern-age strategies that address some of these physiological barriers. The modern age designs include the 3D printed devices and formulations. The superiority of 3D dosage forms over conventional cargos is summarized with a focus on long-acting designs. The innovations in Pharmaceutical organizations (Lyndra, Assertio and Intec) that have taken giant steps towards commercialization of long-acting vehicles are discussed. The recent advancements made in the arena of oral peptide delivery are also highlighted. The review represents a comprehensive journey from Nano-formulations to micro-fabricated oral implants aiming at specific patient-centric designs. [ABSTRACT FROM AUTHOR]

The aim of this study is to develop electrospun gelatin nanofibers based drug delivery carrier to achieve controlled and sustainable release of hydrophobic drug (piperine) for prolonged time. To accomplish this, we devised some strategies such as sandwiching the drug loaded gelatin nanofiber mesh with another gelatin nanofiber matrix without drug (acting as diffusion barrier), sequential crosslinking and finally, a combination of both. As fabricated multilayered electrospun nanofibers mesh was first characterized in terms of degradation study, morphology, drug-polymer interactions, thermal stability followed by studying their release kinetics in different physiological pH as per the gastrointestinal tract. Our results show that with optimized diffusional barrier support and sequential crosslinking together, a zero order sustained drug release up to 48 h may be achieved with a flexibility to vary the drug loading as per the therapeutic requirements. This work lays out the possibility of systematic design of multilayer nano-fiber mesh of a biopolymer as a drug delivery vehicle for hydrophobic drugs with a desired signature of zero order release for prolonged duration. [ABSTRACT FROM AUTHOR]

Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix. [ABSTRACT FROM AUTHOR]