1. A new simple nucleoside synthesis
- Author
-
Konrad Krolikiewicz, H. Vorbriiggen, and B. Bennua‐Skalmowski
- Subjects
chemistry.chemical_compound ,chemistry ,Trimethylsilyl ,Yield (chemistry) ,Organic Chemistry ,Drug Discovery ,Condensation ,Nucleoside synthesis ,Organic chemistry ,Methanol ,Acetonitrile ,Biochemistry ,Trifluoromethanesulfonate - Abstract
Persilylation of excess D-ribose or D-glucose with 6-azauracil or N -benzoyladenine followed by condensation with trimethylsilyl triflate in acetonitrile at 80° affords the corresponding persilylated nucleosides. Transsilylation with methanol and chromatography on SiO2 give the pure free nucleosides in up to 70% yield.
- Published
- 1995
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