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Your search keyword '"Hemaka A. Rajapakse"' showing total 15 results

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15 results on '"Hemaka A. Rajapakse"'

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1. Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1

2. Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing

3. Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors

4. β-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites

5. A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides

6. Asymmetric synthesis of dihydroquinazolinones via directed ortho metalation and addition to tert-butanesulfinyl imines

7. A conformational constraint improves a β-secretase inhibitor but for an unexpected reason

8. Enantioselective total synthesis of altohyrtin C (spongistatin 2)

9. Strategies towards improving the pharmacokinetic profile of ε-substituted lysinol-derived HIV protease inhibitors

10. SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition

11. Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors

12. Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors

13. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

14. Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

15. Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1)

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