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Your search keyword '"Rautio J."' showing total 8 results
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8 results on '"Rautio J."'

1. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.

Author

Gütschow M, Eynde JJV, Jampilek J, Kang C, Mangoni AA, Fossa P, Karaman R, Trabocchi A, Scott PJH, Reynisson J, Rapposelli S, Galdiero S, Winum JY, Brullo C, Prokai-Tatrai K, Sharma AK, Schapira M, Azuma YT, Cerchia L, Spetea M, Torri G, Collina S, Geronikaki A, García-Sosa AT, Vasconcelos MH, Sousa ME, Kosalec I, Tuccinardi T, Duarte IF, Salvador JAR, Bertinaria M, Pellecchia M, Amato J, Rastelli G, Gomes PAC, Guedes RC, Sabatier JM, Estévez-Braun A, Pagano B, Mangani S, Ragno R, Kokotos G, Brindisi M, González FV, Borges F, Miloso M, Rautio J, and Muñoz-Torrero D

Subjects
Animals, Chemistry, Pharmaceutical, Humans, Molecular Targeted Therapy, Pharmaceutical Preparations, Structure-Activity Relationship, Drug Discovery methods
Abstract

Breakthroughs in Medicinal Chemistry [...]., Competing Interests: The authors declare no conflict of interest.

Published
2020
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2. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

Author

Vanden Eynde JJ, Mangoni AA, Rautio J, Leprince J, Azuma YT, García-Sosa AT, Hulme C, Jampilek J, Karaman R, Li W, Gomes PAC, Hadjipavlou-Litina D, Capasso R, Geronikaki A, Cerchia L, Sabatier JM, Ragno R, Tuccinardi T, Trabocchi A, Winum JY, Luque FJ, Prokai-Tatrai K, Spetea M, Gütschow M, Kosalec I, Guillou C, Vasconcelos MH, Kokotos G, Rastelli G, de Sousa ME, Manera C, Gemma S, Mangani S, Siciliano C, Galdiero S, Liu H, Scott PJH, de Los Ríos C, Agrofoglio LA, Collina S, Guedes RC, and Muñoz-Torrero D

Subjects
Humans, Chemistry, Pharmaceutical, Drug Discovery
Abstract

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials that is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...].

Published
2019
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3. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.

Author

Mangoni AA, Eynde JJV, Jampilek J, Hadjipavlou-Litina D, Liu H, Reynisson J, Sousa ME, Gomes PAC, Prokai-Tatrai K, Tuccinardi T, Sabatier JM, Luque FJ, Rautio J, Karaman R, Vasconcelos MH, Gemma S, Galdiero S, Hulme C, Collina S, Gütschow M, Kokotos G, Siciliano C, Capasso R, Agrofoglio LA, Ragno R, and Muñoz-Torrero D

Subjects
Humans, Chemistry, Pharmaceutical trends, Drug Discovery trends
Abstract

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...].

Published
2019
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4. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4.

Author

Mangoni AA, Guillou C, Vanden Eynde JJ, Hulme C, Jampilek J, Li W, Prokai-Tatrai K, Rautio J, Collina S, Tuccinardi T, Sousa ME, Sabatier JM, Galdiero S, Karaman R, Kokotos G, Torri G, Luque FJ, Vasconcelos MH, Hadjipavlou-Litina D, Siciliano C, Gütschow M, Ragno R, Gomes PAC, Agrofoglio LA, and Muñoz-Torrero D

Subjects
Humans, Molecular Targeted Therapy, Drug Discovery methods
Abstract

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules . [...]., Competing Interests: The authors declare no conflict of interest.

Published
2018
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5. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

Author

Muñoz-Torrero D, Mangoni AA, Liu H, Hulme C, Rautio J, Karaman R, de Sousa ME, Prokai-Tatrai K, Sabatier JM, Siciliano C, Luque FJ, Kokotos G, Ragno R, Collina S, Guillou C, Gütschow M, and Agrofoglio LA

Subjects
Chemistry, Pharmaceutical methods, Humans, Drug Discovery methods, Molecular Targeted Therapy methods
Abstract

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which are published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]., Competing Interests: The authors declare no conflict of interest.

Published
2017
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6. Prodrugs--from serendipity to rational design.

Author

Huttunen KM, Raunio H, and Rautio J

Subjects
Animals, Biotransformation, Drug-Related Side Effects and Adverse Reactions prevention & control, Humans, Prodrugs adverse effects, Prodrugs pharmacology, Prodrugs therapeutic use, Technology, Pharmaceutical trends, Drug Design, Drug Discovery, Prodrugs pharmacokinetics
Abstract

The prodrug concept has been used to improve undesirable properties of drugs since the late 19th century, although it was only at the end of the 1950s that the actual term prodrug was introduced for the first time. Prodrugs are inactive, bioreversible derivatives of active drug molecules that must undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then elicit its desired pharmacological effect in the body. In most cases, prodrugs are simple chemical derivatives that are only one or two chemical or enzymatic steps away from the active parent drug. However, some prodrugs lack an obvious carrier or promoiety but instead result from a molecular modification of the prodrug itself, which generates a new active compound. Numerous prodrugs designed to overcome formulation, delivery, and toxicity barriers to drug utilization have reached the market. In fact, approximately 20% of all small molecular drugs approved during the period 2000 to 2008 were prodrugs. Although the development of a prodrug can be very challenging, the prodrug approach represents a feasible way to improve the erratic properties of investigational drugs or drugs already on the market. This review introduces in depth the rationale behind the use of the prodrug approach from past to present, and also considers the possible problems that can arise from inadequate activation of prodrugs.

Published
2011
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7. Breakthroughs in medicinal chemistry: new targets and mechanisms, new drugs, new hopes-7

Author

Gütschow, Michael, Eynde, Jean Jacques Vanden, Jampilek, Josef, Kang, CongBao, Mangoni, Arduino, Fossa, Paola, Karaman, Rafik, Trabocchi, Andrea, Scott, Peter, Reynisson, Jóhannes, Rapposelli, Simona, Galdiero, Stefania, Winum, Jean-Yves, Brullo, Chiara, Prokai-Tatrai, Katalin, Sharma, Arun, Schapira, Matthieu, Azuma, Yasu-Taka, Cerchia, Laura, Spetea, Mariana, Torri, Giangiacomo, Collina, Simona, Geronikaki, Athina, García-Sosa, Alfonso, Vasconcelos, M Helena, Sousa, Maria Emília, Kosalec, Ivan, Tuccinardi, Tiziano, Duarte, Iola, Salvador, Jorge, Bertinaria, Massimo, Pellecchia, Maurizio, Amato, Jussara, Rastelli, Giulio, Gomes, Paula, Guedes, Rita, Sabatier, Jean-Marc, Estévez-Braun, Ana, Pagano, Bruno, Mangani, Stefano, Ragno, Rino, Kokotos, George, Brindisi, Margherita, González, Florenci, Borges, Fernanda, Miloso, Mariarosaria, Rautio, Jarkko, Muñoz-Torrero, Diego, Vanden Eynde, Jean Jacques, Vasconcelos, M. Helena, Gutschow, M., Eynde, J. J. V., Jampilek, J., Kang, C., Mangoni, A. A., Fossa, P., Karaman, R., Trabocchi, A., Scott, P. J. H., Reynisson, J., Rapposelli, S., Galdiero, S., Winum, J. -Y., Brullo, C., Prokai-Tatrai, K., Sharma, A. K., Schapira, M., Azuma, Y. -T., Cerchia, L., Spete, M., Torri, G., Collina, S., Geronikaki, A., Garcia-Sosa, A. T., Helena Vasconcelos, M., Sousa, M. E., Kosalec, I., Tuccinardi, T., Duarte, I. F., Salvador, J. A. R., Bertinaria, M., Pellecchia, M., Amato, J., Rastelli, G., Gomes, P. A. C., Guedes, R. C., Sabatier, J. -M., Estevez-Braun, A., Pagano, B., Mangani, S., Ragno, R., Kokotos, G., Brindisi, M., Gonzalez, F. V., Borges, F., Miloso, M., Rautio, J., Munoz-Torrero, D., Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Gutschow, M, Eynde, J, Jampilek, J, Kang, C, Mangoni, A, Fossa, P, Karaman, R, Trabocchi, A, Scott, P, Reynisson, J, Rapposelli, S, Galdier, S, Winum, J, Brullo, C, Prokai-Tatrai, K, Sharma, A, Schapira, M, Azuma, Y, Cerchia, L, Spete, M, Torri, G, Collina, S, Geronikaki, A, Garcia-Sosa, A, Helena Vasconcelos, M, Sousa, M, Kosalec, I, Tuccinardi, T, Duarte, I, Salvador, J, Bertinaria, M, Pellecchia, M, Amato, J, Rastelli, G, Gomes, P, Guedes, R, Sabatier, J, Estevez-Braun, A, Pagano, B, Mangani, S, Ragno, R, Kokotos, G, Brindisi, M, Gonzalez, F, Borges, F, Miloso, M, Rautio, J, and Munoz-Torrero, D

Subjects
RM, Pharmaceutical research, molecular targeted therapy, Chemistry, Pharmaceutical, MESH: Pharmaceutical Preparations, [SDV]Life Sciences [q-bio], Pharmaceutical Science, animals, chemistry, pharmaceutical, drug discovery, humans, pharmaceutical preparations, structure-activity relationship, Q1, chemistry, 01 natural sciences, Clinical chemistry, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, MESH: Chemistry, Pharmaceutical, Química clínica, MESH: Structure-Activity Relationship, lcsh:Organic chemistry, MESH: Drug Discovery, CHIM/06 - CHIMICA ORGANICA, MESH: Molecular Targeted Therapy, pharmaceutical, MESH: Animals, RM695, Investigació farmacèutica, Physical and Theoretical Chemistry, 030304 developmental biology, 0303 health sciences, MESH: Humans, 010405 organic chemistry, Medicinal Chemistry, New Targets, New Mechanisms, New Drugs, Organic Chemistry, R735, R1, 3. Good health, 0104 chemical sciences, Editorial, n/a, Chemistry (miscellaneous), Molecular Medicine, Breakthroughs, Medicinal Chemistry, medicinal chemistry, targets, drugs, molecules, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules. In these editorials, we highlight in brief reports (of about one hundred words) a number of recently published articles that describe crucial findings, such as the discovery of novel drug targets and mechanisms of action or novel classes of drugs, which may inspire future medicinal chemistry endeavors devoted to addressing prime unmet medical needs.

Published
2020
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8. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

Author

Arduino Mangoni, Jean Eynde, Josef Jampilek, Dimitra Hadjipavlou-Litina, Hong Liu, Jóhannes Reynisson, Maria Sousa, Paula Gomes, Katalin Prokai-Tatrai, Tiziano Tuccinardi, Jean-Marc Sabatier, F. Luque, Jarkko Rautio, Rafik Karaman, M. Vasconcelos, Sandra Gemma, Stefania Galdiero, Christopher Hulme, Simona Collina, Michael Gütschow, George Kokotos, Carlo Siciliano, Raffaele Capasso, Luigi Agrofoglio, Rino Ragno, Diego Muñoz-Torrero, Flinders University [Adelaide, Australia], University of Mons [Belgium] (UMONS), Comenius University in Bratislava, Aristotle University of Thessaloniki, Chinese Academy of Sciences [Beijing] (CAS), Keele University [Keele], Universidade do Porto, University of North Texas Health Science Center [Fort Worth], University of Pisa - Università di Pisa, Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University of Barcelona, University of Eastern Finland, Al-Quds University, University of Siena (University of Siena), University of Naples Federico II, University of Arizona, University of Pavia, University of Bonn, National and Kapodistrian University of Athens (NKUA), University of Calabria, Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Universitat de Barcelona, Universidade do Porto = University of Porto, Università degli Studi di Siena = University of Siena (UNISI), University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli Studi di Pavia = University of Pavia (UNIPV), Universität Bonn = University of Bonn, Università della Calabria [Arcavacata di Rende] (Unical), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Instituto de Investigação e Inovação em Saúde, Leloup, Ludovic, Mangoni, A. A., Eynde, J. J. V., Jampilek, J., Hadjipavlou-Litina, D., Liu, H., Reynisson, J., Sousa, M. E., Gomes, P. A. C., Prokai-Tatrai, K., Tuccinardi, T., Sabatier, J. -M., Luque, F. J., Rautio, J., Karaman, R., Vasconcelos, M. H., Gemma, S., Galdiero, S., Hulme, C., Collina, S., Gutschow, M., Kokotos, G., Siciliano, C., Capasso, Raffaele, Agrofoglio, L. A., Ragno, R., and Munoz-Torrero, D.

Subjects
Chemistry, Pharmaceutical, [SDV]Life Sciences [q-bio], Pharmaceutical Science, Drug Discovery / trends, Química farmacèutica, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, RS, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Drug Discovery, [CHIM] Chemical Sciences, Humans, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, breakthroughs in medicinal chemistry, new targets, new mechanisms, new drugs, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Organic Chemistry, 3. Good health, 0104 chemical sciences, [SDV] Life Sciences [q-bio], Chemistry, Editorial, Chemistry, Pharmaceutical / trends, n/a, Chemistry (miscellaneous), Pharmaceutical, Molecular Medicine, Pharmaceutical chemistry, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules. In these Editorials, we highlight in brief reports (of about one hundred words) a number of recently published articles that describe crucial findings, such as the discovery of novel drug targets and mechanisms of action or novel classes of drugs, which may inspire future medicinal chemistry endeavors devoted to addressing prime unmet medical needs.

Published
2019
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