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22 results on '"Shipeng He"'

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1. Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT

2. Strategies for designing proteolysis targeting chimaeras (PROTACs)

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3. Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer

4. Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation

5. Nucleic-Acid-Based Targeted Degradation in Drug Discovery

6. Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

8. Optimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect

9. Hydrophobic Tagging-Induced Degradation of PDEδ in Colon Cancer Cells

10. Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents

11. Efficient synthesis of artificial pharmaceutical solid-phase modules for constructing aptamer-drug conjugates

13. Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents

14. Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors

15. Structural simplification and bioisostere principle lead to Bis-benzodioxole-fibrate derivatives as potential hypolipidemic and hepatoprotective agents

16. Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA

17. Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran–oxindole derivatives as potent p53-MDM2 inhibitors

18. Design, synthesis and biological evaluation of novel antitumor spirodihydrothiopyran-oxindole derivatives

19. Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael-aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity

20. Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase

21. Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors

22. Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans