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Start Over Descriptor "deep sea natural products" Topic drug discovery
2 results on '"deep sea natural products"'

1. Bioactive Molecules from Extreme Environments II.

Author

Giordano, Daniela and Giordano, Daniela

Subjects
Chemistry, Research & information: general, (DFT)-UV-Vis spectral calculation, 13C-NMR chemical shift linear and multiple regression, 3-amino-2-pyrrolidinone, Antarctic bacteria, Antarctica, Antarctica sponge-derived fungus, Arctic, Arctic/Antarctic, Aspergillus insulicola, Bacillus amyloliquefaciens, DP4 calculation, Dermacoccus abyssi MT 1.1T, Fusarium oxysporum f. sp. cubense, Gastropoda, Lipopolysaccharide (LPS), MALDI-TOF mass spectrometry, Marfey's method, Mariana Trench, Mollusca, Muriellopsis, Paenibacillus, Panama disease, Penicillium griseofulvum, Svalbard, absorption maxima in the near infrared region, anti-food allergy, antibacterial, antibiotics, antifungal activity, antimicrobial peptides, bioactive compound, biomaterials, biotechnological application, chemical ecology, crustin, cyclic tripeptides, deep sea natural products, deep-sea hydrothermal vent, deep-sea microorganism, dermacozine, drug discovery, freeze-drying, fungal metabolites, fungus, green synthesis, iturin A5, lipid A, lipopeptide, lutein, marine bioprospecting, marine biotechnology, marine natural product, marine natural products, metal, microalgae, mycalols, n/a, nanotechnology, phenoxazine, psychrophiles, quinone reductase, shrimp, sponges, spray drying, structural characterization, supercritical fluid extraction, terpene, terpenoid
Abstract

Summary: This Special Issue, as a continuation of the previous Special Issue, "Bioactive Molecules from Extreme Environments" (https://www.mdpi.com/journal/marinedrugs/special_issues/Extreme_Environments accessed on 4 November 2021), includes 10 research articles and 2 reviews, providing a wide overview of the chemical biodiversity offered by different marine organisms inhabiting extreme environments to be used for biotechnological and pharmaceutical applications. The six articles in this Special Issue are focused on the polar regions, which represent an untapped source of marine natural products and are still largely unexplored compared to more accessible sites. Many of these articles refer to Antarctica, which is the coldest and most inaccessible continent on the Earth, where extreme temperatures, light and ice have selected biological communities with a unique suite of bioactive metabolites. The marine organisms of Arctic and Antarctic environments are a reservoir of natural compounds, exhibiting huge structural diversity and significant bioactivities that could be used in human applications.

2. Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV–Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1ᵀ

Author

Bertalan Juhasz, Bastien Cautain, Marcel Jaspars, Carlos Jiménez, Dawrin Pech-Puch, Jioji N. Tabudravu, Kwaku Kyeremeh, and Fernando Reyes

Subjects
Geologic Sediments, Magnetic Resonance Spectroscopy, F163, Light, QH301-705.5, Pharmaceutical Science, Infrared spectroscopy, 01 natural sciences, Dermacoccus abyssi MT 1.1T, Article, phenoxazine, 03 medical and health sciences, chemistry.chemical_compound, absorption maxima in the near infrared region, Mariana Trench, Drug Discovery, Structural isomer, 13C-NMR chemical shift linear and multiple regression, Phenoxazine, Biology (General), Absorption (electromagnetic radiation), Absorption maxima in the near infrared region, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), 030304 developmental biology, 0303 health sciences, Strain (chemistry), 010405 organic chemistry, Dermacozine, Near-infrared spectroscopy, Deep sea natural products, Photochemical Processes, dermacozine, 0104 chemical sciences, Actinobacteria, ¹³C-NMR chemical shift linear and multiple regression, Crystallography, chemistry, Spectrophotometry, Phenazines, Regression Analysis, Density functional theory, Dermacoccus abyssi MT 1.1ᵀ, (DFT)-UV-Vis spectral calculation, Two-dimensional nuclear magnetic resonance spectroscopy, deep sea natural products
Abstract

Three dermacozines, dermacozines N–P (1–3), were isolated from the piezotolerant Actinomycete strain Dermacoccus abyssi MT 1.1T, which was isolated from a Mariana Trench sediment in 2006. Herein, we report the elucidation of their structures using a combination of 1D/2D NMR, LC-HRESI-MSn, UV–Visible, and IR spectroscopy. Further confirmation of the structures was achieved through the analysis of data from density functional theory (DFT)–UV–Visible spectral calculations and statistical analysis such as two tailed t-test, linear regression-, and multiple linear regression analysis applied to either solely experimental or to experimental and calculated 13C-NMR chemical shift data. Dermacozine N (1) bears a novel linear pentacyclic phenoxazine framework that has never been reported as a natural product. Dermacozine O (2) is a constitutional isomer of the known dermacozine F while dermacozine P (3) is 8-benzoyl-6-carbamoylphenazine-1-carboxylic acid. Dermacozine N (1) is unique among phenoxazines due to its near infrared (NIR) absorption maxima, which would make this compound an excellent candidate for research in biosensing chemistry, photodynamic therapy (PDT), opto-electronic applications, and metabolic mapping at the cellular level. Furthermore, dermacozine N (1) possesses weak cytotoxic activity against melanoma (A2058) and hepatocellular carcinoma cells (HepG2) with IC50 values of 51 and 38 μM, respectively.

Published
2021

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