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Start Over Author "Köser, C" Topic drug monitoring
2 results on '"Köser, C"'

1. Clinical standards for the dosing and management of TB drugs.

Author

Alffenaar JWC, Stocker SL, Forsman LD, Garcia-Prats A, Heysell SK, Aarnoutse RE, Akkerman OW, Aleksa A, van Altena R, de Oñata WA, Bhavani PK, Van't Boveneind-Vrubleuskaya N, Carvalho ACC, Centis R, Chakaya JM, Cirillo DM, Cho JG, D Ambrosio L, Dalcolmo MP, Denti P, Dheda K, Fox GJ, Hesseling AC, Kim HY, Köser CU, Marais BJ, Margineanu I, Märtson AG, Torrico MM, Nataprawira HM, Ong CWM, Otto-Knapp R, Peloquin CA, Silva DR, Ruslami R, Santoso P, Savic RM, Singla R, Svensson EM, Skrahina A, van Soolingen D, Srivastava S, Tadolini M, Tiberi S, Thomas TA, Udwadia ZF, Vu DH, Zhang W, Mpagama SG, Schön T, and Migliori GB

Subjects
Humans, Patient Care, Reference Standards, Drug Monitoring, Tuberculosis drug therapy, Antitubercular Agents administration & dosage
Abstract

BACKGROUND: Optimal drug dosing is important to ensure adequate response to treatment, prevent development of drug resistance and reduce drug toxicity. The aim of these clinical standards is to provide guidance on 'best practice´ for dosing and management of TB drugs. METHODS: A panel of 57 global experts in the fields of microbiology, pharmacology and TB care were identified; 51 participated in a Delphi process. A 5-point Likert scale was used to score draft standards. The final document represents the broad consensus and was approved by all participants. RESULTS: Six clinical standards were defined: Standard 1, defining the most appropriate initial dose for TB treatment; Standard 2, identifying patients who may be at risk of sub-optimal drug exposure; Standard 3, identifying patients at risk of developing drug-related toxicity and how best to manage this risk; Standard 4, identifying patients who can benefit from therapeutic drug monitoring (TDM); Standard 5, highlighting education and counselling that should be provided to people initiating TB treatment; and Standard 6, providing essential education for healthcare professionals. In addition, consensus research priorities were identified. CONCLUSION: This is the first consensus-based Clinical Standards for the dosing and management of TB drugs to guide clinicians and programme managers in planning and implementation of locally appropriate measures for optimal person-centred treatment to improve patient care.

Published
2022
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2. Clinical standards for the dosing and management of TB drugs

Author

Alffenaar, J W C, Stocker, S L, Forsman, L Davies, Garcia-Prats, A, Heysell, S K, Aarnoutse, R E, Akkerman, O W, Aleksa, A, van Altena, R, de Oñata, W Arrazola, Bhavani, P K, Van't Boveneind-Vrubleuskaya, N, Carvalho, A C C, Centis, R, Chakaya, J M, Cirillo, D M, Cho, J G, D Ambrosio, L, Dalcolmo, M P, Denti, P, Dheda, K, Fox, G J, Hesseling, A C, Kim, H Y, Köser, C U, Marais, B J, Margineanu, I, Märtson, A G, Torrico, M Munoz, Nataprawira, H M, Ong, C W M, Otto-Knapp, R, Peloquin, C A, Silva, D R, Ruslami, R, Santoso, P, Savic, R M, Singla, R, Svensson, E M, Skrahina, A, van Soolingen, D, Srivastava, S, Tadolini, M, Tiberi, S, Thomas, T A, Udwadia, Z F, Vu, D H, Zhang, W, Mpagama, S G, Schön, T, Migliori, G B, Alffenaar, J W C, Stocker, S L, Forsman, L Davie, Garcia-Prats, A, Heysell, S K, Aarnoutse, R E, Akkerman, O W, Aleksa, A, van Altena, R, de Oñata, W Arrazola, Bhavani, P K, Van't Boveneind-Vrubleuskaya, N, Carvalho, A C C, Centis, R, Chakaya, J M, Cirillo, D M, Cho, J G, D Ambrosio, L, Dalcolmo, M P, Denti, P, Dheda, K, Fox, G J, Hesseling, A C, Kim, H Y, Köser, C U, Marais, B J, Margineanu, I, Märtson, A G, Torrico, M Munoz, Nataprawira, H M, Ong, C W M, Otto-Knapp, R, Peloquin, C A, Silva, D R, Ruslami, R, Santoso, P, Savic, R M, Singla, R, Svensson, E M, Skrahina, A, van Soolingen, D, Srivastava, S, Tadolini, M, Tiberi, S, Thomas, T A, Udwadia, Z F, Vu, D H, Zhang, W, Mpagama, S G, Schön, T, Migliori, G B, and Microbes in Health and Disease (MHD)

Subjects
Pulmonary and Respiratory Medicine, Health Personnel, adverse drug reaction, Cardiorespiratory Medicine and Haematology, Microbiology, 7.3 Management and decision making, Rare Diseases, Clinical Research, qv_771, pharmacodynamics, Humans, tuberculosi, pharmacokinetic, Evaluation of treatments and therapeutic interventions, Reference Standards, dosing, pharmacodynamic, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Infectious Diseases, Orphan Drug, tuberculosis, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, wf_360, Reference Standard, wf_200, Patient Care, Patient Safety, Antimicrobial Resistance, Management of diseases and conditions, Drug Monitoring, Development of treatments and therapeutic interventions, pharmacokinetics, management, Human
Abstract

BACKGROUND: Optimal drug dosing is important to ensure adequate response to treatment, prevent development of drug resistance and reduce drug toxicity. The aim of these clinical standards is to provide guidance on ‘best practice´ for dosing and management of TB drugs.METHODS: A panel of 57 global experts in the fields of microbiology, pharmacology and TB care were identified; 51 participated in a Delphi process. A 5-point Likert scale was used to score draft standards. The final document represents the broad consensus and was approved by all participants.RESULTS: Six clinical standards were defined: Standard 1, defining the most appropriate initial dose for TB treatment; Standard 2, identifying patients who may be at risk of sub-optimal drug exposure; Standard 3, identifying patients at risk of developing drug-related toxicity and how best to manage this risk; Standard 4, identifying patients who can benefit from therapeutic drug monitoring (TDM); Standard 5, highlighting education and counselling that should be provided to people initiating TB treatment; and Standard 6, providing essential education for healthcare professionals. In addition, consensus research priorities were identified.CONCLUSION: This is the first consensus-based Clinical Standards for the dosing and management of TB drugs to guide clinicians and programme managers in planning and implementation of locally appropriate measures for optimal person-centred treatment to improve patient care.

Published
2022

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