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Start Over Author "Heiken, Hans" Topic drug resistance
2 results on '"Heiken, Hans"'

1. Virologic outcomes of switching to boosted darunavir plus dolutegravir with respect to history of drug resistance

Author

Wolf, Eva, Boesecke, Christoph, Balogh, Annamaria, Bidner, Helen, Cordes, Christiane, Heiken, Hans, Krznaric, Ivanka, Kümmerle, Tim, Stellbrink, Hans-Jürgen, Schneider, Jochen, and Spinner, Christoph D.

Subjects
Male, Anti-HIV Agents, Pyridones, Short Report, Drug Resistance, HIV Infections, Protease inhibitors, Middle Aged, Piperazines, Dolutegravir, HIV drug resistance, Oxazines, Integrase inhibitors, HIV-1, Humans, Female, Heterocyclic Compounds, 3-Ring, Darunavir
Abstract

Objective The DUALIS study showed that switching to boosted darunavir (bDRV) plus dolutegravir (DTG; 2DR) was non-inferior to continuous bDRV plus 2 nucleoside/nucleotide reverse-transcriptase inhibitors (NRTIs; 3DR) in treatment-experienced virologically suppressed people living with HIV (PLWH). We analyzed virologic outcomes with respect to treatment history and HIV drug resistance. Design Post hoc analysis of a randomized trial. Methods Main inclusion criteria were an HIV RNA level

Published
2021

2. High effectiveness of recommended first-line antiretroviral therapies in Germany: a nationwide, prospective cohort study

Author

Hoffmann, Christian, Wolf, Eva, Baumgarten, Axel, Wyen, Christoph, Spinner, Christoph D., Jäger, Hans, Postel, Nils, Esser, Stefan, Mueller, Markus, Stoehr, Albrecht, Preis, Stefan, Klauke, Stephan, Schewe, Knud, Kreuzberg, Practice, Schulbin, Hubert, Mayr, Christoph, Schmidt, Wolfgang, Rockstroh, Jürgen, Voigt, Esther, Kümmerle, Tim, Scholten, Stefan, Schneeweiss, Stephan, Fätkenheuer, Gerd, Mauss, Stefan, Bickel, Markus, Lutz, Thomas, Ackermann, Frank, Plettenberg, Andreas, Stellbrink, Hans-Jürgen, Sabranski, Michael, Stoll, Matthias, Heiken, Hans, Pauli, Ramona, Becker, Werner, Bogner, Johannes, Christensen, Stefan, Ulmer, Albrecht, Wasem, Jürgen, and Neumann, Anja

Subjects
0301 basic medicine, Microbiology (medical), Adult, Male, medicine.medical_specialty, First line, 030106 microbiology, Medizin, HIV Infections, Drug resistance, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Germany, medicine, Humans, Protease inhibitor (pharmacology), 030212 general & internal medicine, Prospective Studies, Prospective cohort study, business.industry, General Medicine, High effectiveness, Middle Aged, VIROLOGIC FAILURE, Regimen, Infectious Diseases, Anti-Retroviral Agents, HIV-1, Observational study, Female, business
Abstract

Current German/Austrian antiretroviral treatment guidelines recommend more than 20 combination regimens for first-line therapy, without a preference. Regimens include two nucleoside reverse transcriptase inhibitors (NRTIs) plus either an integrase strand transfer inhibitor (INSTI), a non-NRTI (NNRTI) or a boosted protease inhibitor (PI). The objective was to examine the outcomes of recommended first-line ART in Germany. This nationwide observational study included treatment-naive chronically HIV-1 infected patients receiving one of the recommended first-line regimens. Patients were allocated to three arms (INSTI, NNRTI, PI) and were prospectively followed for 24 months. Delayed treatment initiation was defined by a baseline CD4 T-cell count of

Published
2020

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