1. The HLA- A*2402/ Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population.
- Author
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Moon, Jangsup, Park, Han‐Ki, Chu, Kon, Sunwoo, Jun‐Sang, Byun, Jung‐Ick, Lim, Jung‐Ah, Kim, Tae‐Joon, Shin, Jung‐Won, Lee, Soon‐Tae, Jung, Keun‐Hwa, Jung, Ki‐Young, Jeon, Daejong, Kim, Dong Wook, Yu, Kyung‐Sang, Jang, In‐Jin, Kang, Hye‐Ryun, Park, Heung‐Woo, and Lee, Sang Kun
- Subjects
HLA histocompatibility antigens ,LAMOTRIGINE ,CARBAMAZEPINE ,STEVENS-Johnson Syndrome ,DRUG side effects ,KOREANS ,DIAGNOSIS ,THERAPEUTICS ,DISEASES - Abstract
The use of lamotrigine ( LTG) can be limited by the occurrence of cutaneous adverse drug reactions (c ADRs) that range from maculopapular eruption ( MPE) to the more severe Stevens-Johnson syndrome and toxic epidermal necrolysis. A few human leukocyte antigen ( HLA)-related genetic risk factors for carbamazepine-induced cADR have been identified. However, the HLA-related genetic risk factors associated with LTG-induced cADR are not yet well known. We performed HLA genotyping in 50 Korean patients with epilepsy, including 21 patients presenting LTG-induced MPE and 29 LTG-tolerant patients. A significant association between the HLA-A*2402 allele and LTG-induced MPE was identified, in comparison with the LTG-tolerant group (odds ratio [ OR] 4.09, p = 0.025) and the general Korean population ( OR 3.949, p = 0.005). The frequencies of the Cw*0102 or Cw*0702 alleles were significantly higher in the LTG- MPE group than in the Korean population, whereas the frequency of the A*3303 allele was lower. The coexistence of the A*2402 and Cw*0102 alleles was significantly associated with the LTG- MPE group when compared to the LTG-tolerant group ( OR 7.88, p = 0.007). In addition, the Cw*0701 allele was more frequent in the LTG-tolerant group than in the Korean population. These findings suggest the presence of HLA-related genetic risk factors for LTG-induced MPE in the Korean population. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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