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Restless legs syndrome (RLS) is a common condition characterized by dysesthesia (such as a painful burning, prickling, or aching feeling) in the legs and an irresistible urge to move the [...]

Magnesium Prevents Cisplatin-Induced Nephrotoxicity Fifty-eight patients with head and neck cancer who received cisplatin-based chemotherapy were studied retrospectively. Twenty-nine of these patients, treated after January 2012, were given 10 mmol [...]

Autism is a developmental disorder that begins before the age of three years. Manifestations may include abnormalities of communication and social interaction; repetitive, restricted, and self-injurious behaviors; intellectual disability; and [...]

You may have noticed the recent ad blitz for Aimovig (erenumab), a new drug for migraine prevention that was approved by the US Food and Drug Administration (FDA) in May [...]

Vitamin Dosage for HIV Patients Some 3418 Tanzanian patients with human immunodeficiency virus (HIV) infection who were initiating highly active antiretroviral therapy (HAART) were randomly assigned to receive, in double-blind [...]

Probiotic Improves Irritable Bowel Syndrome Fifty-nine children (aged 4-18 years; mean, 12.5 years) with irritable bowel syndrome were randomly assigned to receive, in double-blind fashion, VSL#3 (a probiotic) or placebo [...]

Calcium and vitamin D may prevent cancer. One thousand, one hundred seventy-nine women residing in Nebraska and older than 55 years were randomly assigned to receive (method blinding not specified) [...]

On July 7, 2017, the US Food and Drug Administration (FDA) approved Endari[TM] (Emmaus Life Sciences; Torrance, CA) for the treatment of sickle cell disease (SCD). Endari is the only [...]

Ninety-six patients (aged 28-55 years) with melasma (disease duration, 2-6 years) were randomly assigned to apply, in double-blind fashion, silymarin cream (7 mg or 14 mg of silymarin per ml) [...]

Age-related macular degeneration (AMD) is the most common cause of progressive visual loss and blindness in developed countries. At least 10% of Americans over age 65 have some visual loss [...]

Last year, Roche, the giant Swiss pharmaceutical company, prematurely terminated a large-scale clinical trial of dalcetrapib, a drug that increases HDL-cholesterol levels by inhibiting cholesterol ester transfer protein. In the [...]

Two hundred fifty-three women with dyspareunia associated with menopause were randomly assigned to receive, in double-blind fashion, placebo, 3.25 mg of dehydroepiandrosterone (DHEA), or 6.5 mg of DHEA, administered intravaginally [...]

One hundred-forty patients with chronic urticaria that had not responded to conventional therapy consumed a pseudoallergen-free diet for three weeks. Twenty patients (14.3%) were considered strong responders, 19 patients (13.6%) [...]

Fifty patients with mild-to-moderate ulcerative colitis that had failed to respond sufficiently to mesalamine were randomly assigned to receive, in double-blind fashion, 3 g per day of curcumin (in 2 [...]

Fifty-five women (aged 18-45 years) with adult acne were randomly assigned to receive topical 15% azelaic acid gel twice a day or 0.1% adapalene gel once a day for 9 [...]

One hundred fifty-three patients aged 50 years or older (mean age, 63 years) with major depression who were being treated with citalopram (a selective serotonin-re uptake inhibitor) were randomly assigned [...]

Eighty patients (mean age, 75.3 years) with mild-to-moderate Alzheimer's disease who were receiving standard therapy (acetylcholinesterase inhibitors with or without memantine) were randomly assigned to receive, in double-blind fashion, 2 [...]

A 34-year-old female consulted me because of a history of fatigue, low energy, and sensitivity to cold throughout most of her life. Other symptoms included waves of nausea, with no [...]

One hundred twenty-five patients with cirrhosis and minimal hepatic encephalopathy were randomly assigned to receive, in double-blind fashion, acetyl-L-carnitine (ALC; 2 g, twice a day) or placebo for 90 days. [...]

Two more studies have now joined other research showing that policosanol derived from sugar cane wax is ineffective as a treatment for hypercholesterolemia. In one of these studies, 99 patients [...]

Healthy volunteers ingested 150 mg or 300 mg of quercetin-4'-O-beta-D-glucoside, a form of quercetin that is present in various fruits and vegetables and in high levels in onions, and that [...]

A 56-year-old woman with rapidly progressive, platinum-resistant ovarian cancer began self-treatment with four ounces per day of Haelan951, a commercially available fermented soy beverage. The disease stabilized during a nine-month [...]

A 58-year-old woman with a history of obsessive-compulsive disorder since childhood had a stable but partial response to fluvoxamine (Luvox; a selective serotonin-reuptake inhibitor), which she had been taking for [...]

One hundred-fifty overweight or obese infertile women (mean age, 29 years; range, 18-39 years) with polycystic ovary syndrome (PCOS) who had failed to ovulate after treatment with clomiphene citrate were [...]

One hundred-fifty-three patients (mean age, 60.3 years) who had had a first acute myocardial infarction three to 21 days previously were randomly assigned to receive, in double-blind fashion, L-arginine or [...]

The author of this report has found amebas of the genus Naegleria in synovial tissue and other tissues of patients with rheumatoid disease. These amebas have also been found to [...]

Two hundred fifty-one patients with papulopustular rosacea with persistent erythema and telangiectasia were randomly assigned to receive, in double-blind fashion, a 15% azelaic acid gel or 0.75% metronidazole gel. The [...]

A recent study in the New England Journal of Medicine demonstrated that once-weekly prophylactic oral administration of 150 mg of fluconazole (Diflucan®) can greatly reduce the recurrence rate of vulvovaginal [...]

Twenty postmenopausal women (aged 50-65 years) received 25 mg/day of dehydroepiandrosterone (DHEA) orally for 12 months. The mean serum concentrations of testosterone, estrone, and estradiol increased significantly and progressively, each [...]

Two hundred fifty-one women in New Delhi, India, in their first pregnancy were randomly assigned to receive, in doubleblind fashion, lycopene (from a tomato extract), 2 mg twice a day, [...]

One hundred-twenty women with active systemic lupus erythematosus (SLE) were randomly assigned to receive, in double-blind fashion, 200 mg/day of DHEA or placebo for 24 weeks. During the study, 18.3% [...]

Forty-five men (mean age, 56.7 years) with erectile dysfunction (ED) were randomly assigned to receive, in a 3-way double-blind crossover trial, 1) 3.25 of L-arginine (provided by 6 g of [...]

Twenty-six boys (aged 6-13 years) with attention-deficit hyperactivity disorder (ADHD) were randomly assigned to receive, in double-blind fashion, one of two treatment protocols: placebo-carnitine-placebo or carnitine-placebo-carnitine. Each treatment period lasted [...]

In a double-blind crossover study of persons over age 50 years, 15 individuals with normal sleep patterns (controls) and 15 who had decreases in sleep efficiency received, in random order, [...]

Using a large national insurance database in the US, 4724 children (mean age, 3.1 years) diagnosed with gastroesophageal reflux disease (GERD) who were treated with gastric acid suppressive (GAS) medications [...]

301 Dorwood Drive * Carlisle, Pennsylvania 17013 Iron restriction beneficial in hepatitis C Seventeen patients (mean age, 54 years) with chronic hepatitis C who did not respond to, or were [...]

One hundred women with polycystic ovary syndrome (mean age, 23 years; mean body mass index [BMI], 23.5 kg/[m.sub.2]), who had hirsutism and irregular menses, were randomly assigned to receive conventional [...]

Colchicine is an anti-inflammatory drug derived from the autumn crocus plant. It has been used successfully for more than 100 years for the acute treatment of gout. It is also [...]

A recent controlled trial found that in patients with renal failure that had not yet progressed to the point of requiring dialysis, treatment with an antianemia drug (i.e., a drug [...]

A 46-year-old female had a 7-year history of to systemic lupus erythematosus (SLE). After treatment with N-acetylcysteine (NAC; 600 mg 3 times per day), chronic 3 + proteinuria improved to [...]

Two hundred fifty patients with chronic low back pain associated with degenerative lumbar osteoarthritis were randomly assigned to receive, in double-blind fashion, 1500 mg per day of glucosamine sulfate or [...]

Forty men (mean age, 56.5 years) with erectile dysfunction were studied. None of the men had well-known causes of erectile dysfunction, such as hypertension, diabetes, or ischemic heart disease. All [...]

Fifty-four patients with premature cardiovascular disease (55 years and under for men, 65 years and under for women) who were homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C[right arrow]T polymorphism (i.e., [...]

I saw a 38-year-old man with a long history of seasonal allergic rhinitis, which occurred each spring and lasted about a month. Symptoms included nasal congestion, itchy eyes, and fatigue. [...]

The records were reviewed of 107 children (aged 2-18 years) with autism spectrum disorders who had received melatonin because of insomnia. Melatonin was given 30-60 minutes before bedtime. Children less [...]

In the Treatment of Peripheral Osteoporosis (TROPOS) study, 5091 postmenopausal women (mean age, 77 years) with osteoporosis who were not receiving any antiosteoporosis medications were randomly assigned to receive, in [...]

Fifty-five men and 58 women (aged 65-75 years) were randomly assigned to receive, in double-blind fashion, 50 mg per day of dehydroepiandrosterone (DHEA) or placebo for one year. Thereafter, all [...]

Serum 25-hydroxyvitamin D levels were measured in 621 patients receiving a statin drug, of whom 128 were experiencing myalgia. The mean 25-hydroxyvitamin D level was significantly lower in the symptomatic [...]

Four hundred forty-three patients with chronic painful neuropathy were treated with 600 mg per day of alphalipoic acid (ALA) for a mean period of five years. ALA was then stopped, [...]

One hundred-fifty patients with dry eye syndrome were randomly assigned to receive vitamin A eye drops (Viva Drops; Vision Pharmaceuticals) 4 times per day, 0.05% cyclosporine A eye drops twice [...]