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Purpose: In the last decade over 17.46 million people in India died due to wrong medication and drug-drug interaction. In fact, Drug-drug interaction is the 4th leading cause of death in India. Medications used in COVID-19 management had resulted in one in five patients experiencing adverse drug reactions. Polypharmacy and self-medication are recognized as increasingly serious mortality and morbidity problem in the current healthcare system. Materials and Methods: Pharmasure software is scripted in HTML and JavaScript. It requires very less storage space, and thus the device with less storage can perform more efficiently and effectively without any internet bugs. In this model drug interaction are included on the basis of literature and pharmaceutical journals which show dispensing and prescription errors due to drug-drug interaction. The drug interactions were studied, reviewed and scripted in the programme. Results: Result of Pharmasure comes out as, it make easy for physician and pharmacists to check drug interactions. Pharmasure has different tabs featuring Drug interaction, Drug Food interaction, Herb Drug interaction and Pediatric dose calculation. Pharmasure is one of its kind which shows different healthcare aid at same place. Conclusion: The Present work corroborates that harm and death due to drug-drug interaction can be prevented. People should have information of drug interaction. Pharmasure has different healthcare features on one platform. [ABSTRACT FROM AUTHOR]