1. Murine models of graft versus host disease (GVHD): Focus on ocular GVHD.
- Author
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Steven P, Perez VL, and Sharma A
- Subjects
- Animals, Mice, Disease Models, Animal, Dry Eye Syndromes etiology, Hematopoietic Stem Cell Transplantation adverse effects, Graft vs Host Disease metabolism, Lacrimal Apparatus metabolism
- Abstract
Graft versus host disease (GVHD) remains a major and serious complication of allogeneic hematopoietic stem cell transplantation. Based on the time of onset, clinical phenotypes, progression kinetics, and pathophysiology, GVHD is stratified into acute, chronic, and overlapping types. The eyes are among the most commonly affected organs in GVHD. Mouse models have played an important role in understanding the several key elements of GVHD pathobiology. The current review discusses the immunology, pathology, and key phenotypic features of mouse models of systemic GVHD. Furthermore, a critical appraisal of mouse models of ocular GVHD (oGVHD) is provided. The disease mechanisms underlying the ocular surface, meibomian gland, and lacrimal gland injury in these models are reviewed, and the relevance of oGVHD murine models to clinical oGVHD is also included., Competing Interests: Declaration of competing interest Authors do not have any financial conflict of interest to disclose., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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