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Although current code guidelines specify different seismic performance objectives for fixed-base and isolated buildings, the future of performance-based design will allow user-selected performance objectives, motivating the need for a consistent performance comparison of the two systems. Based on response history analysis to a suite of motions, constant ductility spectra are generated for fixed-base and isolated buildings. Both superstructure force (base shear) and deformation demands in base-isolated buildings are lower than in fixed-base buildings responding with identical deformation ductility. To compare the relative performance of many systems or to predict the best system to achieve a given performance objective, a response index is developed and used for rapid prototyping of response as a function of system characteristics. When evaluated for a life safety performance objective, the superstructure design base shear of an isolated building is competitive with that of a fixed-base building with identical ductility, and the isolated building generally has improved response. Isolated buildings can meet a moderate ductility immediate-occupancy objective at low design strengths, whereas comparable ductility fixed-base buildings fail to meet the objective. [ABSTRACT FROM AUTHOR]