Author: "Del Bianco T" / Topic: duodenal ulcer - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Del Bianco T" Topic duodenal ulcer

Author: Dal Santo P, Vianello F, Germana B, Del Bianco T, Laino G, Grassi SA, Plebani M, Dotto P, Battaglia G, and Di Mario F
Subjects: Adult, Duodenal Ulcer drug therapy, Duodenal Ulcer epidemiology, Female, Gastric Juice chemistry, Histamine H2 Antagonists therapeutic use, Humans, Male, Recurrence, Risk Factors, Smoking epidemiology, Bicarbonates metabolism, Duodenal Ulcer physiopathology, Gastric Juice metabolism, Gastric Mucosa metabolism, Smoking physiopathology
Abstract: Gastric bicarbonate secretion has been evaluated by Feldman's method in 48 duodenal-ulcer patients. The relationship between smoking, clinical ulcer outcome (healing and recurrence) and bicarbonate secretion has been analysed. Heavy smokers secreted higher bicarbonate ions than did non-smokers. High-relapsing patients produced lower bicarbonate output. These preliminary data suggest that an impaired gastric bicarbonate secretion is associated with smoking, a well-known ulcer-associated factor; further-more, it may single out high-relapsing duodenal ulcer patients.
Published: 1993

Author: Dal Santo PL, Vianello F, Germana B, Dotto P, Laino G, Del Bianco T, Plebani M, Leandro G, Savarino V, and Di Mario F
Subjects: Adult, Aged, Duodenal Ulcer physiopathology, Female, Gastric Juice metabolism, Gastric Mucosa physiopathology, Humans, Infusions, Intravenous, Male, Middle Aged, Pentagastrin, Anti-Ulcer Agents therapeutic use, Bicarbonates metabolism, Duodenal Ulcer drug therapy, Gastric Acid metabolism, Gastric Acidity Determination, Gastric Juice drug effects, Gastric Mucosa drug effects, Pepsinogens metabolism, Piperazines therapeutic use
Abstract: To study the effect of Esaprazole, a new antiulcer drug, on acid, peptic and alkaline secretion a modified gastric acid test was performed in 18 duodenal ulcer patients. Pentagastrin was administered as bolus 30' and 75' after the beginning of the test, followed by Esaprazole 300 mg i.v. at 90'. Gastric juice was collected every 15' for determination of: total volume, volume of non parietal secretion, acid, bicarbonate and pepsin output. Serum pepsinogen group I was determined by radioimmunoassay. Esaprazole had a significant inhibitory effect on the total volume of gastric secretion and on volume of non parietal secretion. Pepsin output and serum pepsinogen group I were not affected by Esaprazole, while bicarbonate secretion was reduced. Antiulcer activity of Esaprazole seems to be due to the reduction of total volume of gastric secretion.
Published: 1993

Author: Dal Santo, P. L., Fabio Vianello, Germana, B., Dotto, P., Laino, G., Del Bianco, T., Plebani, M., Leandro, G., Savarino, V., and Di Mario, F.
Subjects: Adult, Male, Gastric Juice, Pepsinogens, Gastric Acidity Determination, Middle Aged, Anti-Ulcer Agents, Piperazines, Gastric Acid, Bicarbonates, Gastric Mucosa, Duodenal Ulcer, Humans, Female, Pentagastrin, Infusions, Intravenous, Aged
Abstract: To study the effect of Esaprazole, a new antiulcer drug, on acid, peptic and alkaline secretion a modified gastric acid test was performed in 18 duodenal ulcer patients. Pentagastrin was administered as bolus 30' and 75' after the beginning of the test, followed by Esaprazole 300 mg i.v. at 90'. Gastric juice was collected every 15' for determination of: total volume, volume of non parietal secretion, acid, bicarbonate and pepsin output. Serum pepsinogen group I was determined by radioimmunoassay. Esaprazole had a significant inhibitory effect on the total volume of gastric secretion and on volume of non parietal secretion. Pepsin output and serum pepsinogen group I were not affected by Esaprazole, while bicarbonate secretion was reduced. Antiulcer activity of Esaprazole seems to be due to the reduction of total volume of gastric secretion.

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