1. Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences.
- Author
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Berbers RM, Nierkens S, van Laar JM, Bogaert D, and Leavis HL
- Subjects
- Animals, Autoimmunity, Common Variable Immunodeficiency immunology, Dysbiosis microbiology, Evidence-Based Medicine, Homeostasis, Humans, Immunomodulation, Inflammation microbiology, Models, Immunological, Common Variable Immunodeficiency microbiology, Dysbiosis immunology, Gastrointestinal Microbiome immunology, Immunity, Mucosal, Inflammation immunology
- Abstract
Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic immune dysregulation. Here, we critically review the current evidence for a role of the microbiome in the pathogenesis of CVID immune dysregulation, and describe the possible immunologic mechanisms behind causes and consequences of microbial dysbiosis in CVID. We integrate this evidence into a model describing a role for the gut microbiota in the maintenance of inflammation and immune dysregulation in CVID, and suggest research strategies to contribute to the development of new diagnostic tools and therapeutic targets., (Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
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