1. Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola.
- Author
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Legardy-Williams, Jennifer K., Carter, Rosalind J., Goldstein, Susan T., Jarrett, Olamide D., Szefer, Elena, Fombah, Augustin E., Tinker, Sarah C., Samai, Mohamed, and Mahon, Barbara E.
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VACCINES , *PREGNANCY , *EBOLA virus disease , *EBOLA virus disease prevention , *COMMUNICABLE disease epidemiology , *PREVENTION of communicable diseases , *RESEARCH , *VIRAL vaccines , *IMMUNIZATION , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *PREGNANCY outcomes , *COMPARATIVE studies , *PREGNANCY complications , *BLIND experiment , *PRENATAL care - Abstract
Little information exists regarding Ebola vaccine rVSVΔG-ZEBOV-GP and pregnancy. The Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) randomized participants without blinding to immediate or deferred (18-24 weeks postenrollment) vaccination. Pregnancy was an exclusion criterion, but 84 women were inadvertently vaccinated in early pregnancy or became pregnant <60 days after vaccination or enrollment. Among immediate vaccinated women, 45% (14/31) reported pregnancy loss, compared with 33% (11/33) of unvaccinated women with contemporaneous pregnancies (relative risk 1.35, 95% CI 0.73-2.52). Pregnancy loss was similar among women with higher risk for vaccine viremia (conception before or <14 days after vaccination) (44% [4/9]) and women with lower risk (conception >15 days after vaccination) (45% [10/22]). No congenital anomalies were detected among 44 live-born infants examined. These data highlight the need for Ebola vaccination decisions to balance the possible risk for an adverse pregnancy outcome with the risk for Ebola exposure. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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