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Obesity is a condition where the body is overweight due to fat accumulation, each exceeding 20-25% of body weight for men and women. L-carnitine is a nutrient that plays a role in transporting fat to the mitochondria to be burned and converted into energy for the body. Sufficient L-carnitine allows the body to burn fat at optimal levels. This research aims to determine the side effects of fed L-carnitine supplements against liver histology. This study used a completely randomized design (CRD) with four groups comprising six albino rats. The treatments were fed orally by distilled water 1 ml/day (Control), P1 fed by L-carnitine supplement dose 100 mg/kg body weight orally 1ml/day, P2 fed by L-carnitine supplement dose 150 mg/kg body weight orally 1ml/day, P3 fed by L-carnitine supplement dose 200 mg/kg body weight orally 1ml/day. Treatments were given to albino rats every day for 90 days. Variables observed measured were lipid degeneration, central vein dilation, and pyknotic nuclei. Data were analyzed with the statistical program (SPSS 22.0 for Windows) with One Way ANOVA. The results showed that feeding L-carnitine supplements in high doses for long periods can damage the liver cells of male rats. The microscopic liver damage statistical analysis showed significant differences (P

Antioxidant compounds are vital for the body. An imbalance in the body's levels of free radicals and antioxidants will cause oxidative stress and cause disease because free radicals will damage the surrounding molecules (lipids, proteins, and nucleic acids), causing damage to tissues and cells. Today many studies are interested in using natural antioxidants in food, beverages, cosmetics, and therapies derived from plants. Centella asiatica is a plant often used as a source of antioxidants because it contains active compounds such as terpenoids, flavonoids, polyphenols, tannins, carotene, and vitamin C, which have antioxidant activity. In addition to containing 78% menthol, mint leaves contain resin and tannins, which are several polyphenolic antioxidants that prevent or neutralize the effects of free radicals. Antioxidants are compounds that can delay, slow down, or inhibit oxidation reactions and fight free radicals. The results showed that the antioxidant activity of the combination of Centela asiatica leaf extract and mint leaf extract based on the results of the analysis showed that it was included in the strong category.